摘要
目的对硫必利治疗乙醇所致精神障碍的疗效及安全性进行评价。方法将38例乙醇所致精神障碍病人随机分为治疗组和对照组各19例,治疗组应用硫必利治疗,剂量0.2～0.6 g/d;对照组应用地西泮治疗,剂量20～30 mg/d,观察时间均为10 d,采用简明精神病量表(BPRS)、汉密顿焦虑量表(HAMA)、汉密顿抑郁量表(HAMD)和副反应量表(TESS)评定疗效和不良反应。结果治疗组和对照组的显效率分别为78.9%和84.2%,两组比较差异无显著性(P>0.05);对照组出现白细胞减少1例,GPT轻度升高1例,而治疗组仅出现口干2例,视物略模糊2例,轻度静坐不能1例,未出现严重不良反应。结论盐酸硫必利注射液可以明显改善慢性乙醇中毒引起的神经精神症状,其疗效与地西泮注射液相当,且不良反应少,安全性好。
Objective To evaluate the efficacy and safety of Tiapride on patients with alcohol-induced mental disorder.Methods Thirty-eight patients were equally randomized to two groups： treatment group and control group.The patients in the treatment group were treated with Tiapride（0.2-0.6 g/d）,and those in the control received Diazepam（20-30 mg/d）.The therapy lasted for 10 days.The efficacy and adverse effects were assessed by using BPRS,HAMA,HAMD and TESS. Results The excellence rates of Tiapride and Diazepam were 78.9% and 84.2%,respectively,with no significant difference between the two groups（P0.05）.Leukopenia（one case） and slightly elevated GPT（one case） were seen in the control;while in the treatment group,dry mouth occurred in two cases,blurred vision in two,and mild akathisia in one.No severe side effects were recorded.Conclusion Tiapride Hydrchloride injection can obviously improve the neuropsychic symptoms caused by chronic alcoholism,its curative effect is comparable to that of Diazepam injection with less side effects and higher safety.
出处
《齐鲁医学杂志》
2011年第2期159-160,共2页
Medical Journal of Qilu
关键词
乙醇相关性障碍
硫必利
地西泮
治疗结果
alcohol-related disorders
tiapride
diazepam
treatment outcome
