摘要
目的应用斑点追踪显像（STI）技术评价舒张性心力衰竭（DHF）和收缩性心力衰竭（SHF）兔模型的左室扭转及解旋运动的特点。方法33只雄性新西兰兔分为三组：分别为DHF模型组（12只）、SHF模型组（11只）及对照组（10只）。应用STI技术评估左室扭转，并行左室导管及心肌病理学检查。结果与对照组相比，DHF组左室峰值扭转角度（Ptw）无显著变化（P〉0．05），SHF组Ptw减低，两组的解旋均延迟，等容解旋率减低，DHF组的左室解旋峰速（PUTV）增加，SHF组的PuTV减低（P〈0．05）。两组的Ptw均与左室收缩功能指标呈正相关。SHF组的PuTV与左室导管舒张功能指标呈正相关。结论STI可有效评价SHF和DHF兔左室扭转和解旋运动。
Objective To assess left ventricular twist and untwist in rabbit models with diastolic heart failure（DHF） and systolic heart failure（SHF） by speckle tracking imaging（STI）. Methods Thirty- three male New Zealand rabbits were divided into three groups：one group was used to establish DHF model by suprarenal abdominal aortic constriction（ n = 12） and the other was used to establish SHF model by abdominal aortic constriction subdiaphragmly above celiac artery origin（ n = 11）, another was control group established by sham operation（ n = 10）. After two weeks, left ventricular twist-related parameters were measured, by STE. Finallly, left ventricular catheterization and myocardial pathological examination were performed. Results Compared with control group,peak twist angle （Ptw） and peak twisting velocity（PTV） remained unchanged in DHF group （ P 〉 0.05） and decreased in SHF group （ P 〈 0.05）. Isovolumic untwisting rate （IUR） decreased, untwisting half-time（UHT） was prolonged, time to peak twist （tPtw） and peak untwisting velocity（tPUTV）were delayed in SHF and DHF groups. In additon, Peak untwisting velocity（PUTV） decreased in SHF group, but increased in DHF group（ P 〈0.05）. Ptw correlated correlated positively with LVEF, ＋ dp/dtmax significantly in both groups （DHF group： r = 0. 897, P = 0. 002; r = 0. 719, P = 0. 044;SHF group： r = 0. 727, P = 0. 041; r = 0. 780, P = 0. 022）. A significantly positive correlation was observed between PUTV and - dp/dt Tau,LVEDP（ r = 0. 801, P = 0. 0173 r = 0. 814, P = 0. 014; r = 0. 875, P = 0. 004） in SHF group. Conclusions STI is useful in evaluating left ventricular twist and untwist in rabbit model of DHF and SHF.
出处
《中华超声影像学杂志》
CSCD
北大核心
2011年第3期253-257,共5页
Chinese Journal of Ultrasonography
