摘要
目的观察糖皮质激素治疗结核性胸膜炎的疗效及对炎症细胞因子白细胞介素-6(IL-6)和白细胞介素-8(IL-8)的影响。方法 60例结核性胸膜炎患者按照用药方式分为胸腔注射组和口服用药组。两组患者均给予常规抗结核化疗方案,胸腔注射组给予地塞米松3mg注入胸腔内治疗,对照组给予常规口服糖皮质激素治疗。治疗前和治疗9d后采用酶联免疫吸附试验方法测定胸腔积液中IL-6和IL-8水平,治疗1个月后评价疗效。结果治疗组总有效率为96.7%,显著高于对照组(66.7%),差异有统计学意义;治疗后,胸腔注射组IL-6、IL-8水平下降,与对照组比较有差异有统计学意义。结论糖皮质激素治疗结核性胸膜炎能够影响胸腔积液中IL-6及IL-8的释放,具有抑制胸腔局部免疫细胞作用的功能;能显著改善临床疗效,值得推广应用。
Objective To observe the influence of glucocoricoid by intrathoracic injection on clinical efficacy and inflammatory cytokines interleukin-6（IL-6） and interleukin-8（IL-10） in patients with tuberculous pleurisy.Methods 60 patients with tuberculous pleurisy were randomly divided into injection group and oral group.The patients of two groups were treated using conventional anti-TB chemotherapy,on the basis of conventional anti-TB chemotherapy the injection group was treated using dexamethasone treatment 3mg by intrathoracic injection and the oral group was treated using conventional oral corticosteroid therapy.Before treatment and 9 days after treatment the levels of the IL-6 and IL-8 in pleural fluid were tested by ELISA method,and clinical efficacy was evaluated 1 month after.Results The clinical total effective rate of the injection group was 96.7%,it was significantly higher than that of the control group（66.7%）,compared with the control group the difference was significant;After treatment,the IL-6 and IL-8 levels of injection group decreased,compared with the oral group the difference was significant.Conclusion The glucocoricoid by intrathoracic injection in treatment of tuberculous pleurisy can affect IL-6 and IL-8 release,and can inhibit the function of local immune cells in pleural.It can significantly improve the clinical efficacy and it is worthy to be popularized.
出处
《实用心脑肺血管病杂志》
2011年第4期560-561,共2页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
关键词
结核性胸膜炎
糖皮质激素
胸腔注射
炎症细胞因子
疗效
Tuberculous pleurisy
Glucocoricoid
Intrathoracic injection
Inflammatory cytokines
Clinical efficacy
