摘要
目的研究抗结核药物联合胸腺肽对老年结核性胸膜炎患者的治疗效果及对炎性因子的影响。方法选取2014年10月至2015年10月华北石油管理局总医院结核科治疗的老年结核性胸膜炎患者72例,根据随机数字表法分成两组。对照组(n=35)按照常规治疗方法行Seldinger技术+抗结核药物治疗;观察组(n=37)同时联合胸腺肽辅助治疗。治疗2个月,观察疗效并记录胸腔积液完全吸收时间,观察两组患者治疗前后胸膜厚度的改变及胸腔积液中炎症因子的变化,以酶联免疫吸附测定法于治疗前后对患者外周血γ干扰素(IFN-γ)、白细胞介素2(IL-2)[由辅助性T细胞(Th)1分泌]和IL-4、IL-10(由Th2分泌)进行检测。结果观察组总有效率显著高于对照组[94.6%(35/37)比71.4%(25/35)],差异有统计学意义(P=0.021);治疗后,观察组的胸膜厚度显著少于对照组[(1.19±0.26)mm比(1.41±0.31)mm,P<0.05];观察组胸腔积液完全吸收时间显著短于对照组[(35.7±3.6)d比(43.4±3.8)d,P<0.05];两组治疗1、3个月IFN-γ、IL-2均呈下降趋势,且观察组下降速度更快,IL-4、IL-10均呈上升趋势,且观察组上升速度更快,两组在组间、时点间、组间·时点间交互作用差异有统计学意义(P<0.05)。结论早期应用抗结核药物同时联合胸腺肽注射液可有效提高老年患者免疫力,有效预防胸膜增厚,提高临床疗效。
Objective To study the effects of anti-tuberculosis drugs combined with thymosin on tuber- culous pleurisy treatment and inflammatory factors in the elderly patients. Methods Total of 72 elderly patients with tuberculous pleurisy in Department of Tuberculosis, General Hospital of North China Petroleum Administration Bureau from Oct. 2014 to Oct. 2015 were divided into two groups according to the random number table method, to the control group （ n = 35 ） received the conventional treatment methods with Seldinger technique and anti-tuberculosis drug treatment;the observation group（ n = 37 ） Was combined with thymosin adjuvant therapy. The treatment lasted for 2 months,and the efficacy,complete absorption of pleura1 effusion time, pleural thickness change and pleural effusion inflammatory factors were observed and recorded, the peripheral blood [FN-Y,IL-2 （Th1 cell secreted） and IL-4,IL-10 （Th2 cell secreted） were detected by enzyme linked immunosorbent assay （ELISA） method. Results The total efficacy of the observation group was significantly higher than the control group[94. 6 （35/37） vs 71.4 （25/35） ] ,the difference was statisti- cally significant（P =0. 021 ） ; after treatment, the pleural thickness of the observation group was significantly less than the control group [ （ 1.19 ± 0. 26 ） mm vs （ 1.41 ± 0. 31 ） mm, P 〈 0.05 ]. The pleural effusion complete absorption time of the observation group was shorter than the control group [ （ 35.7 ± 3.6） d vs （43.4 ± 3.8 ） d, P 〈 0. 05 ] ; after 1 and 3 months of treatment, IFN-Y and IL-2 of both groups were de- creased, and the observation group decreased faster, IL-4, IL-10 showed a rising trend, and the observation group rose faster, the differences between groups, time points,interaction of groups time points were statisti- cally significant （P 〈 0. 05 ）. Conclusion Early application of anti-tubereulosis drugs combined with thymo- sin injection can improve the immunity of the elderly patients, which is e
出处
《医学综述》
2016年第21期4354-4357,共4页
Medical Recapitulate
关键词
老年结核性胸膜炎
抗结核药物
胸腺肽
炎性因子
Senile tuberculous pleurisy
Anti-tuberculosis drugs
Thymosin
Inflammatory factors
