摘要
目的:探讨胰岛素样生长因子结合蛋白-3(IGFBP-3)与先天性甲状腺功能减低(CH)儿童智力发育的关系。方法:用免疫放射分析法测定IGFBP-3,应用CDCC及C-WYCSl分别对2～岁及3～7岁儿童进行智力测定。结果:①两组儿童智商均在正常范围,但病例组低于正常组(P<0.05)。②IGFBP-3在2～岁儿童中差异无统计学意义(P>0.05),3～7岁儿童中病例组低于正常组(P<0.05)。③在2～岁儿童组中IGFBP-3与智商无统计学相关性(P>0.05),在3～7岁儿童中IGFBP-3与语言智商、韦氏总智商呈正相关(P<0.05)。以IGFBP-3值为因变量,以儿童韦氏各项测验得分为自变量,进行多元逐步回归分析,智能因素中对IGFBP-3水平影响较大的前6位因子分别为图片词汇、领悟、倒背、迷津、视觉分析、顺背。结论:①早期确诊并及时治疗的CH儿童可避免出现智能发育障碍,但仍存在认知方面的损害;②CH儿童经过早期治疗后,血清IGFBP-3水平仍低于正常儿童;③IGFBP-3水平与儿童的语言智商发育更密切;④CH可造成IGFBP-3低水平表达而影响儿童智能发育。
Objective：To explore the relationship between insulin-like growth factor binding protein-3（IGFBP-3） and intelligence development of children with congenital hypothyroidism（CH）.Methods：Immunoradiometric assay was used to detect the expression level of IGFBP-3,CDCC and C-WYCSI were used to determine the levels of intelligence of children aged 2~ years old and 3~7 years old.Results：The intelligence quotients of the two groups were within normal range,but the intelligence quotient in case group was lower than that in control group（P0.05）.Among the children aged 2~ years old,there was no significant difference in expression level of IGFBP-3 between case group and control group（P0.05）;among the children aged 3~7 years old,the expression level of IGFBP-3 in case group was lower than that in control group（P0.05）.Among the children aged 2~ years old,there was no correlation between IGFBP-3 and intelligence quotient（P0.05）;among the children aged 3~7 years old,there was a positive correlation between IGFBP-3 and linguistic IQ,Verbal intelligence quotient（P0.05）.IGFBP-3 level was selected as dependent variable,the scores of various tests in C-WYCSI were selected as independent variable,multivariate regression analysis was carried out,among intelligent factors,the first six effect factors of IGFBP-3 level were picture vocabulary,understanding,memory inverse order,maze,visual analysis and reciting orderly.Conclusion：For the children with CH,early diagnosis and timely treatment can avoid disorder of intelligence development,but injury of cognition exists;after early treatment,the serum level of IGFBP-3 in the children with CH is still lower than that in normal children;the level of IGFBP-3 is related to development of linguistic IQ in children;CH may induce low expression of IGFBP-3 and affect the development of intelligence in children.
出处
《中国妇幼保健》
CAS
北大核心
2011年第12期1818-1821,共4页
Maternal and Child Health Care of China
