摘要
目的 探讨先天性甲状腺功能减低症（CH）最佳治疗时机。方法 选取我院2008年1月至2013年1月收治的120例治疗随访时间〉2年的CH患儿作为研究对象,根据患儿开始治疗时间的不同分为三组,即≤1个月者50例,1~3个月39例,3~5个月31例。所有患儿均给予左旋甲状腺素钠治疗。比较三组患儿6个月及2岁时的体格发育情况和甲状腺功能情况,观察患儿2岁时的智力发育情况。结果 三组患儿6个月、2岁时的身长和体重比较,差异有显著的统计学意义（P〈0.01）,随初始治疗时间的推迟,晚期治疗组患儿身长、体重明显低于早期治疗组。三组患儿2岁时的MDI、PDI评分比较,差异具有统计学意义（P〈0.05）,随初始治疗时间的推迟,患儿MDI、PDI评分越来越低。三组患儿6个月、2岁时的FT3、FT4及TSH水平比较,差异无统计学意义（P〉0.05）。结论 CH患儿初始治疗时间与智力、体格发育明显相关,早期诊断、早期治疗可有效改善患儿的预后。
Objective To discuss the optimal therapy time of congenital hypothyroidism （CH）. Methods 120 cases of children with congenital hypothyroidism whose follow-up time 〉2 years admitted to our hospital from January 2008 to January 2013 were selected as research subjects. According to different beginning time of the treatment, the children were divided into three groups, with the time ≤ one month in 50 cases, 1 - 3 months in 39 cases, 3 - 5 months in 31 cases. All patients were treated with levothyroxine sodium. The physical development and thyroid function at the sixth month and the age of two were compared, and the intelligence development at the age of two was observed. Results The body length and body weight of three groups at the sixth month and the age of two had statistically significant difference （P 〈0.01）; with the delay of the exact treatment time, the body length and body weight of late treatment group were significantly lower than those of early treatment group. The MDI score and PDI score of three groups at the age of two had statistical difference （P〈0.05）; with the delay of the exact treatment time, the MDI score and PDI score decreased continuously. The level of FT3, FT4 and TSH of three groups at the sixth month and the age of two had no statistical difference （P〉0.05）. Conclusions The initial treatment time of CH children is significantly related to patients＇ intelligence and physical development. Early diagnosis and early treatment can effectively improve the prognosis of children.
出处
《临床医学工程》
2015年第12期1625-1627,共3页
Clinical Medicine & Engineering
