摘要
目的观察阿托伐他汀钙联合羟乙基淀粉注射液治疗急性脑分水岭梗死(ACWI)的疗效。方法 100例ACWI患者,随机、单盲分为治疗组、对照组(n=50),对照组给予常规治疗,治疗组在常规治疗的基础上加用阿托伐他汀钙和羟乙基淀粉注射液治疗14天,治疗后第7、14天采用美国国立卫生院脑卒中量表(NIHSS)予以评分,并在治疗后3、6个月采用改良的Rankin评分(mRS)及Barthel指数(BI)进行远期疗效评价。结果治疗后第7、14天治疗组NIHSS评分明显低于对照组(P<0.05)。治疗后3、6个月治疗组BI、mRS明显优于对照组(P<0.05)。治疗后6个月治疗组82.61%患者临床结局良好,优于对照组的62.22%(P<0.05)。未见明显不良反应。结论阿托伐他汀钙联合羟乙基淀粉注射液治疗ACWI安全、有效。
Objective To evaluate the efficacy and safety of atorvastatin calcium combined with hydroxyethyl starch in the treatment of acute cerebral watershed infarction（ACWI）.Methods One hundred patients with ACWI were randomly divided into treatment and control groups（n=50 each）.The control group received conventional therapy,and the treatment group was administered with atorvastatin calcium ＋ hydroxyethyl starch injection for 14 days beside the conventional therapy.The theraupetic effects were evaluated by the National Institutes of Health Stroke Scale（NIHSS） 7 and 14 days after treatment.The long-term efficacy was evaluated by the modified Rankin Score（mRS） and Barthel Index（BI） 3 and 6 months after treatment.Results The NIHSS score in the treatment group was significantly lower than that in the control group 7 and 14 days after treatment（P0.05）.After 3 and 6 months of treatment,the BI and mRS in the treatment group were significantly superior to controls（P0.05）.Good clinical outcomes were noted in 82.61% of patients in the treatment group compared with 62.22% in the control group（P0.05） 6 months after treatment.No adverse events were found.Conclusions Atorvastatin calcium combined with hydroxyethyl starch for treatment of ACWI is effective and safe.
出处
《国际神经病学神经外科学杂志》
2010年第6期487-490,共4页
Journal of International Neurology and Neurosurgery
关键词
急性脑分水岭梗死
阿托伐他汀钙
羟乙基淀粉注射液
疗效
不良反应
acute cerebral watershed infarction
atorvastatin calcium
hydroxyethyl starch
curative effect
adverse effect
