摘要
目的:初步探讨葛根素注射液引起新西兰兔急性血管内溶血的剂量及出现溶血的时间。方法:200,160,80,40,20,0mg.kg-1各组动物分别耳缘静脉注射给予葛根素注射液4mL.kg-1,并于给药前、给药后5,20min,1,2,8,24,48,72h耳缘静脉采血,进行血清胆红素,血浆血红蛋白,血液红细胞计数、血红蛋白、红细胞容积的测定。结果:80,160,200mg.kg-1组家兔的游离血浆血红蛋白、血清胆红素给药后5min至8h显著升高,与对照组比较有明显差异(P<0.05)。结论:高剂量葛根素注射液可引起新西兰兔急性血管内溶血。
OBJECTIVE To investigate the dose- and time-dependent of acute hemolysis induced by puerarin injection in rabbits. METHODS Rabbits were randomly divided into puerarin 200,160,80,40,20 mg.kg 1 groups and control group. According to the dosage of drug puerarin were via auricular vein intravenously injected at 4 mL.kg i. The blood were collected at 5,20 min, 1, 2,8,24,48 and 72 h after drug administratiorL The content of serum bilirubin, plasma free hemoglobin, blood cell count, blood red cell volume and blood hemoglobin were measured. RESULTS Compared with control group, the plasma hemoglobin and serum bilirubin in 80,160 and 200 mg kg^-1 groups were significantly increased at 5 min to 8 h after the administration of puerarin injection. CONCLUSION Puerarin injection, at dosage above 80 mg. kg^-1 , can induce acute hemolysis in rabbits.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2011年第8期676-678,共3页
Chinese Journal of Hospital Pharmacy
