摘要
目的:探讨不同血压水平与外周动脉疾病患病的关系。方法:选取我国9个地区的15817名35岁以上居民作为研究对象,进行踝臂指数测量(踝臂指数≤0.9诊断为外周动脉疾病),并收集相关危险因素资料。采用Logistic回归模型分析不同血压水平与外周动脉疾病的关系。结果:单因素分析显示,随着血压水平的升高,外周动脉疾病的患病风险呈上升趋势(趋势检验P<0.05)。在调整了性别(仅针对全人群)、年龄、城乡、吸烟、超重/肥胖、高总胆固醇血症以及糖尿病病史等的影响后,与正常血压组相比较,正常高值血压组、1级高血压组、2级高血压组、3级高血压组患外周动脉疾病的OR值分别为1.11(95%CI:0.94～1.32),1.13(95%CI:0.93～1.38),1.85(95%CI:1.47～2.33),2.66(95%CI:1.98～3.57)(趋势检验P<0.05)。结论:随着血压水平的升高,外周动脉疾病患病风险升高,将血压控制在正常范围内可能对预防外周动脉疾病有重要意义。
Objective：To explore the relationship between different blood pressure levels and peripheral arterial disease （PAD）assessed by ankle-brachial index （ABI）. Methods： Data including ABI,blood pressure,health history,medication use,blood biochemistry and physical examinations derived from 15 817 subjects from 9 areas throughout China were analyzed. Univariate and multivariate adjusted Logistic regression analyses were used for the data analyses. Results： Blood pressure levels were classified into 5 levels as normal blood pressure,high normal blood pressure,primary hypertension,secondary hypertension and the third grade of hypertension. With the increasing of blood pressure levels,the risk of PAD gradually increased （Ptrend〈0.05）. In comparison with normal blood pressure group,the ORs of PAD for the other groups were 1.10（95%CI： 0.93-1.29）,1.17（95% CI： 0.97-1.40）,1.91（95% CI： 1.55-2.37）,and 2.64（95% CI： 1.99-3.49）,respectively. After adjusting for gender（only for total population）,age,urban/rural,smoke,obesity/overweight,the history of hypercholesterolemia and diabetes,the ORs were 1.11（95%CI： 0.94-1.32）,1.13（95% CI： 0.93-1.38）,1.85（95% CI： 1.47-2.33）,and 2.66（95% CI： 1.98-3.57） （Ptrend 〈0.05）. Conclusion：PAD risk increases in proportion with the increasing blood pressure level.
出处
《北京大学学报（医学版）》
CAS
CSCD
北大核心
2010年第6期667-670,共4页
Journal of Peking University:Health Sciences
基金
国家"十五"科技攻关项目(2001BA703B01)资助~~
关键词
高血压
外周血管疾病
危险因素
Hypertension； Peripheral vascular disease； Risk factor；
