摘要
提出将980 nm和1064 nm半导体激光组合应用于皮肤组织伤口焊接,通过肉眼观察、病理学检测以及张力测试等方法对比了双波长激光焊接与传统缝线术的缝合效果。同时,利用热电偶温度测试系统在体测量了激光焊接皮肤切口过程中的组织内部温度,研究激光焊接效果与组织温度之间的关系。结果表明,980 nm和1064 nm激光同时以0.5 W连续输出,功率密度为15.92 W/cm2,每点照射时间为5 s模式组合焊接时,伤口缝合效果与传统缝线术相比具有伤口闭合迅速、愈合快、伤口表面平整、异物反应小、伤口闭合紧等优点。由此可见,双波长激光组织焊接是一种有效的伤口闭合方法,有待进一步研究以便应用于临床。
Skin welding with a combination of 1064 nm and 980 nm diode lasers, which＇s the first-time discuss in the literature, was performed in this study. The long-time effect of laser skin welding was investigated through macroscopic and microscopic examinations as well as tensile strength tests at different time after the welding, comparing with that of conventional suturing. At the same time, the temperature of rat skin tissue during laser- welding was measured in vivo with a thermo-couple temperature measurement in order to analysis the relation between the effect of tissue welding and tissue temperature. Using a power density of 15.92 W/cm^2 with power of 0.5 W in continuous wave mode and exposure time of 5 seconds per spot for both 980 nm and 1064 nm lasers, it＇s found that laser tissue welding yielded more effective closure and healing than conventional suturing technique that with faster recovery, better apposition of tissue, less tissue interaction and tighter closure. As a result, tissue welding with a combination of two near-infrared lasers is an effective method for wound closure, and further investigations are in progress for clinical use.
出处
《中国激光》
EI
CAS
CSCD
北大核心
2011年第4期100-106,共7页
Chinese Journal of Lasers
基金
苏州市科技发展项目(SYJG0904)
中国科学院苏州生物医学工程技术研究所专项筹备资金(O91901L090)资助课题
关键词
医用光学
激光组织焊接
半导体激光
伤口愈合
张力
组织温度
medical optics
laser tissue welding
diode lasers
wound healing
tensile strength
tissue temperature
