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HER-2和Top-Ⅱα可作为乳腺癌化疗疗效的预测因子 被引量：3

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摘要 一般认为,HER-2过表达或基因扩增的乳腺癌患者预后差。近期的8个大型随机临床试验和基于这些临床研究的荟萃分析均证实:与不含蒽环类药物方案相比,HER-2阳性乳腺癌患者更易从含蒽环类药物方案中获益。另有研究发现,Top-Ⅱα基因缺失提示预后不良,Top-Ⅱα扩增提示患者对蒽环类药物的高缓解率。因此,HER-2与蒽环类药的相关性可能与Her-2基因和Top-Ⅱα(拓扑异构酶Ⅱα)基因同在17号染色体的相邻位置有关。有关Her-2阳性对高剂量蒽环类或紫杉类药物化疗敏感的观点,仍有待于更多的临床试验证实。本文结合已发表的乳腺癌辅助化疗临床试验结果,分析了Her-2和Top-Ⅱα基因对化疗敏感性的预测作用。
作者 王佳玉 徐兵河
机构地区 中国医学科学院协和医学院肿瘤医院肿瘤研究所内科
出处 《临床药物治疗杂志》 2011年第2期45-49,共5页 Clinical Medication Journal
关键词 乳腺癌化疗 预测因子 HER-2 Top-Ⅱα 蒽环类药物 紫杉类药物
分类号 R737.9 [医药卫生—肿瘤]
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参考文献41

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同被引文献24

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临床药物治疗杂志
2011年 第2期

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