摘要
目的观察升陷汤加味方对兔病态窦房结综合征模型心率、窦房结功能和心肌Na+-K+-ATP酶的影响。方法将30只大耳白兔随机分成六组:空白组、模型组、心宝组、升陷汤加味方高、中、低剂量组,各组先连续灌胃给药7 d,再行造模,测量并观察心率、窦房结功能和心肌Na+-K+-ATP酶活力的变化。结果各用药组心率、窦房结功能和心肌Na+-K+-ATP酶活力变化均优于模型组(P<0.05),其中升陷汤加味方高剂量组以上各指标与心宝组比较,差异无统计学意义(P>0.05);升陷汤加味方中、低剂量组改善各指标作用不及心宝组,两组分别与心宝组比较,差异均有统计学意义(P<0.05)。结论升陷汤加味方可提高兔病态窦房结综合征模型的心率,保护窦房结功能,提高心肌Na+-K+-ATP酶活力,提高窦房结细胞抗损害能力。
Objective To observe the impacts of modified shengxian decoction on heart rate,sinus node function and myocardial Na＋-K＋-ATP in the rabbit model of myocardial sick sinus syndrome.Methods 30 big ear white rabbits were randomized into six groups：blank group,model group,xinbao group,and high-dose,medium-dose and low-dose groups of shengxian decoction.Medication with gastric lavage was done continuously for 3 days in each group,then,the model was settled.Finally,heart rate,sinus node function and myocardial Na＋-K＋-ATP activity were measured and observed.Results The changes in heart rate,sinus node function and myocardial Na＋-K＋-ATP activity in every medication group were superior to model group（P0.05）.Of them,the levels of the above indexes in high-dose group of modified shengjiang decoction were not different significantly as compared with xinbao group in statistics（P0.05）.The improvements in the indexes of medium-dose and low-dose groups of modified shengjiang decoction were not superior to xinbao group,indicating significant difference in statistical comparison of the groups（P0.05）.Conclusion Modified shengxian decoction may improve heart rate of sick sinus syndrome of rabbit model,protect sinus node function,enhance myocardial Na＋-K＋-ATP activity and strengthen the ability of sinus cell to conquer damage.
出处
《世界中西医结合杂志》
2011年第3期199-202,共4页
World Journal of Integrated Traditional and Western Medicine
基金
河北省中医药管理局科研计划课题(No.2009212)
关键词
病态窦房结综合征
升陷汤加味方
动物实验
Sick Sinus Syndrome
Modified Shengxian Decoction
Animal Experiment
