摘要
目的观察短疗程糖皮质激素治疗早期亚急性肝功能衰竭患者的临床疗效及安全性。方法选择乙型病毒性肝炎早期亚急性肝功能衰竭患者87例;分治疗组43例,对照组44例;其中对照组采用拉米夫定抗乙型肝炎病毒及常规综合治疗,治疗组在采用与对照组相同治疗的基础上联合短疗程糖皮质激素治疗;分别观察其救治成功率、平均住院日及不良反应,并进行相互比较。结果治疗组患者救治成功率明显高于对照组,住院日中位数明显小于对照组,差异均有统计学意义(P均<0.05);两组患者并发症发生率差异无统计学意义(P>0.05)。结论短疗程糖皮质激素治疗乙型病毒性肝炎早期亚急性肝功能衰竭,可以提高患者救治成功率,缩短患者病程;严格把握糖皮质激应用指征及治疗时机,并联合有效的抗HBV治疗,临床应用比较安全。
Objective To assess the therapeutic effect and safety of short-term low-dose glucocorticoid in the treatment of early-stage subacute liver failure.Methods Eight-seven patients with early-stage HBV-related subacute liver failure were randomized into glucocorticoid treatment group（n=43） and control group（n=44）.The patients in the control group received lamivudine and routine integrated treatment）,and those in the treatment group were given additional short-term low-dose glucocorticoid treatment.The endpoint measurements included the survival rate,mean hospital stay and adverse reactions to the treatments.Results The patients receiving glucocorticoid treatment exhibited significantly greater improvement of the liver functions than those in the control group（P0.05）.The rate of successful treatment was significantly higher in treatment group with shortened hospital stay（P0.05）,but the virological response rate and incidence of complications showed no significant differences between the two groups（P0.05）.Conclusion The short-term low-dose glucocorticoid treatment can improve survival rate and shorten the mean hospital stay of patients with HBV-related early-stage subacute liver failure patients.Gulcocorticoid treatment is relatively safe when administered with strictly controlled indications and time window for intervention,
出处
《南方医科大学学报》
CAS
CSCD
北大核心
2011年第3期554-556,共3页
Journal of Southern Medical University
关键词
糖皮质激素
肝功能衰竭
乙型肝炎
拉米夫定
glucocoriticoid
liver failure
early-staged
hepatitis B
lamivudine
