摘要
从断奶乳猪新鲜肝脏提取的肝细胞生长素(HGF)注入经四氯化碳(CCl_4)诱发的大鼠慢性中毒性肝损伤模型的腹腔内,观察 HGF 对肝损伤的保护作用。结果发现 HGF 具有:1.降低转氨酶(与对照组比较有显著差异,P<0.05);2.改善蛋白代谢,降低γ-球蛋白;3.抑制肝脏纤维组织增生(羟脯氨酸含量和肝组织纤维化均比对照组明显降低和减少)等作用;4.超微结构在 HGF 组比对照组也有明显改善,尤以线粒体和粗面内质网为明显。本实验证实 HGF 可以对 CCl_4诱导的慢性肝损伤起到肝细胞再生和保护作用。
In this experiment, injection of HGF was prepared from the fresh weanling pigliver and administered peritoneally to rats with chronic toxic liver injury induced bycarbon tetrachloride, in order to observe the protective effect of HGF. The resultsshowed that, HGF was able (1) to lower down serum ALT leve lwith significantdifference (P<0.05) comparing with normal saline control group; (2) to improveprotein metabolism, reducing serum γ-globulin level; (3) to inhibit the hepatic fibroustissue hyperplasia, for marked decrease in hydroxyprcline content and hepatic fibrosiswere found in the HGF treatment group in contrast to the control group; (4)significantly to improve and restore the ultrastructure of the injured hepatocytesinduced by CCl_4 toxicty, particularly the mitochondia and rough endoplasmicreticulum.Thus, it was confirmed that HGF had the hepatocyte regenerative and protec-tive effects on chronic to(?)ic liver injury induced by carbon tetrachloride.
出处
《天津医药》
CAS
1990年第9期539-541,共3页
Tianjin Medical Journal
