摘要
1例91岁男性冠心病患者,近1年服用文拉法辛150 mg/d治疗抑郁/焦虑症。因精神症状加重拟停用文拉法辛换用他药,遂将文拉法辛减为75 mg/d,1 d后停用。次日晨患者意识突然丧失,10 min后恢复,血压50/30 mm Hg(1 mm Hg=0.133kPa)。给予多巴胺治疗。第2天患者心电图示急性心肌梗死;诊断为文拉法辛撤药综合征。给予阿司匹林、氯吡格雷、硝酸甘油及喹硫平等治疗,之后,患者明显好转,住院20 d出院。
A 91-year-old man with coronary artery disease received venlafaxine 150 mg/day for treatment of anxiety/depression for about one year.Because of his aggravated mental symptoms,the withdrawal of venlafaxine and the administration of other drugs were planned.Subsequently,venlafaxine was decreased to 75 mg/day,and then discontinued 1 day.The next day morning,the patient suddenly developed unconsciousness and,10 minutes later,he regained consciousness.His blood pressure was 50/30 mm Hg.He was treated with dopamine.The second day,acute myocardial infarction was confirmed by ECG,and venlafaxine withdrawal syndrome was diagnosed.The patient was given aspirin,clopidogrel,nitroglycerin,and quetiapine.Later,the patient markedly improved and,after 20 days of hospitalization,he was discharged.
出处
《药物不良反应杂志》
2011年第1期56-58,共3页
Adverse Drug Reactions Journal
关键词
文拉法辛
撤药综合征
低血压
急性心肌梗死
venlafaxine
withdrawal symptom
hypotension
acute myocardial infarction
