摘要
目的利用基于体素形态学技术比较听力正常人与感音神经性耳聋人的脑白质之间差异。方法分别对20例听力正常人及20例感音神经性耳聋人进行常规T2-WI与三维(3D)快速扰相梯度回波(FSPGR)采集脑结构图像。用VBM技术运算,然后观察2组脑质差异并显示出差异脑区的MNI坐标及差异容积,然后对所得数据进行相应统计学分析。结果听力正常组脑白质增多的区域有(P<0.01,Clustersize=30):左侧颞上回、左侧额中回、左侧顶叶(半卵圆中心)、左侧楔前叶、左侧额下回、左侧颞上回、左侧中央后回、左侧小脑半球、右侧颞上回。结论感音神经性聋人在左、右侧颞上回白质减少,提示其白质发生萎缩。
Objective To investigate the difference in cerebral white matter between healthy people and the patients with sensorineural hearing loss by voxel-based morphology comparison.Methods Both 20 cases of normal hearing subjects and 20 cases of sensorineural deafness were scaned with GE 3.0T MRI scaner to get routine T2WI and three-dimensional（3D） fast spoiled gradient echo（fast spoiled gradient echo,FSPGR） collection of brain structure image.The observed qualitative differences in the brain according to VBM between the two groups would demonstrate the differences between the MNI coordinates of brain regions and the differences in volume,then the data were statistically analyzed.Results The increasing areas of cerebral white matter in normal hearing subjects（Cluster size=50,P0.01）were the left superior temporal gyrus,left middle frontal gyrus,left parietal lobe（semi-oval center）,the left anterior lobe wedge,wedge the left anterior lobe,left lateral inferior frontal gyrus,left superior temporal gyrus,the left,after the central back,the left cerebellar hemisphere,right superior temporal gyrus.However the increasing areas of white matter in sensorineural hearing loss patients（Cluster size=50,P0.01）were the left inferior parietal lobule,left temporal gyrus,the right inferior temporal gyrus.Conclusion The cerebral white matter is decreased in the patients with sensorineural deaf in the left and right superior temporal gyrus,which suggests that the cerebral white matter occures atrophy.
出处
《河北医药》
CAS
2011年第5期663-665,共3页
Hebei Medical Journal
