摘要
目的了解内镜下覆膜支架置入对晚期食管癌患者生活质量的影响。方法采用欧洲癌症研究与治疗组织生存质量问卷第3版(EORTCQLQ-C30V3.0)和食管癌专用量表(QLO-OES18)对2004年9月至2008年10月在我院进行覆膜支架置入治疗的伴有吞咽困难的38例无法手术治疗的晚期食管癌患者在治疗前、治疗后1周、4周和12周进行生存质量评估。结果覆膜支架置入后患者整体生活质量(37.8±14.9对74.3±10.8;P<0.01)和所有功能领域生活评分显著提高并持续到治疗后12周。患者吞咽困难症状明显改善(18.9±24.5对90.8±7.9;P<0.01),并持续到治疗后12周。梗阻(48.1±27.5对18.3±30.5;P<0.01)和进食(25.2±15.7对5.1±18.7;P<0.01)等症状方面均有显著改善。结论覆膜支架置入能够显著提高患者的整体生存质量和全部功能领域评分,并能改善患者的吞咽困难和梗阻等症状。
Objective To investigate the effects of membrane covered esophageal stenting on the quality of life（QOL）in patients with advanced esophageal cancer.Methods A total of 38 patients with dysphagia due to inoperable esophageal cancer between September 2004 and October 2008 underwent membrane covered esophageal stent placement.The QOL was assessed using Chinese version of European Organization for Research and Treatment of cancer quality of life（EORTC QLQ-C30 V3.0）and EORCT QLQ-Esophagus（OES-18）questionnaire before and at 1,4,and 12 weeks after placement of the stent.Results The global health status（37.8 14.9 vs.74.3 10.8;P0.01）and all functional scores improved significantly after stenting from baseline until 12 weeks.Dysphagia improved significantly immediately after stenting,and this improvement persisted until 12 weeks（18.9 24.5 vs.90.8 7.9;P0.01）.There was significant improvement in deglutition（48.1 27.5 vs.18.3 30.5;P0.01）and eating（25.2 15.7 vs.5.1 18.7;P0.01）following stenting.Conclusion Membrane covered esophageal stenting resulted in significant improvement of global health status and all functional domain and some symptoms such as dysphagia and deglutition.
出处
《中国肿瘤临床与康复》
2010年第6期574-576,F0003,共4页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
内镜
食管肿瘤
覆膜食管支架
恶性食管狭窄
生活质量
Endoscope
Esophageal neoplasms
Membrane covered esophageal stent
Malignant esophageal strictures
Quality of life
