摘要
目的观察游泳训练对糖尿病大鼠学习记忆功能及iNOS,nNOS mRNA表达的影响。方法选用雄性SD大鼠40只,随机分为正常对照组、模型对照组、游泳训练组。采用链脲佐菌素静脉注射复制糖尿病模型,游泳训练组运动6周后应用Morris水迷宫法观察游泳训练对糖尿病大鼠学习记忆的影响,并测定大鼠脑组织iNOS mRNA和nNOS mRNA的表达。结果游泳训练组大鼠脑组织iNOS mRNA显著低于模型对照组,nNOS mRNA显著高于模型对照组。结论游泳训练能增加糖尿病大鼠脑组织nNOS mRNA含量,降低iNOS mRNA,从而对糖尿病大鼠学习与记忆障碍有一定程度的改善。
Aim To detect the effect of swimming exercise on the cognitive ability of rats with diabetics and the expression of iNOS mRNA and nNOS mRNA in brain.Methods The rat diabetes model was induced by injecting streptozocin,and then the rats were randomly divided into three groups： control group,diabetes mellitus untreated group and swimming exercise group.After six weeks of swimming exercise treatment,memory was examined with the device of Morris water maze.The expression of iNOS mRNA and nNOS mRNA in brain was detected.Results The rats in swimming exercise group showed an increase of learning ability（P0.05） with more expression of nNOS mRNA（P0.05） and a weaker expression of iNOS mRNA（P0.05）.Conclusion Swimming exercise can decrease the expression of iNOS mRNA and increase the expression of nNOS mRNA,swimming exercise can improve diabetes rats′ abilities of learning and memory.
出处
《西北大学学报（自然科学版）》
CAS
CSCD
北大核心
2011年第1期77-80,共4页
Journal of Northwest University（Natural Science Edition）
基金
陕西省自然科学基金资助项目(2003C137)
西北工业大学科技创新基金资助项目(2008KJ02046)
关键词
游泳训练
糖尿病
学习记忆
swimming exercise
Diabetes
study and memory function
