摘要
目的探讨Kimura病的临床病理学特征、免疫学表型。方法分析10例Kimura病的临床资料和组织学形态,应用免疫组织化学研究其免疫表型。结果 10例Kimura多见于男性患者,一般状态均较好。好发于头颈部,多表现为皮下多发性结节或局部肿胀,部分病例伴有区域淋巴结肿大。组织学上,病变位于真皮内或皮下,均以增生的淋巴组织为主,可见淋巴滤泡形成,含有活跃的生发中心,滤泡间可见大量增生的毛细血管后微静脉型血管,其内皮呈肿胀状或扁平状,血管周围和滤泡旁可见大量嗜酸性粒细胞浸润,6例内可见嗜酸性微脓肿形成。免疫组织化学显示,Kimura病中的淋巴滤泡表达B细胞抗原,滤泡间的淋巴细胞多表达T细胞标记。结论 Kimura病是一种具有特殊临床病理表现的炎性增生性病变,应与部分富含淋巴组织的肿瘤相鉴别,组织病理学对于诊断有着十分重要的意义。
Objective To observe the clinicopathologic features and immunophenotypes of patients with Kimura′s disease（KD）.Methods Clinical data of 10 KD cases were analyzed and examined by light microscopy and immunohistochemistry.Results The patients were predominantly males with relatively good condition.KD developed most frequently in the head and neck region and usually presented as multiple subcutaneous nodules or swellings and was accompanied by lymphadenopathy in some cases.Histologically,KD lesions could involve in the dermis or subcutis.All KD cases displayed florid hyperplasia of lymphoid tissue and exhibited formation of lymphoid follicles and active germinal centers.Proliferation of post-capillary venules was seen between follicles.They were lined by plump or attenuated endothelial cells.Large number of eosinophils aggregated around the vessels or adjacent to the follicles.Formation of microabscesses was observed in 6 cases.Immunohistochemical study in KD revealed B cells in the lymphoid follicles and mostly T cells in the interfollicular regions.Conclusions KD is a benign disease with characteristic inflammatory proliferation in histipathology.It should be differentiated from tumor abundant lymph tissue.The histopathologic diagnosis of KD is important.
出处
《江苏医药》
CAS
CSCD
北大核心
2011年第4期459-461,F0003,共4页
Jiangsu Medical Journal
