摘要
本研究旨在探究复方天葡片(compound tianpupian,TPP)及其组分对小鼠红细胞氧化损伤的保护作用。采用小鼠红细胞自氧化及过氧化氢氧化损伤模型,通过扫描电镜和分光光度计法观察TPP及其组分对红细胞氧化损伤的保护作用。结果表明,TPP明显抑制过氧化氢导致的红细胞氧化损伤,其4种组分红景天、葡萄籽提取物原花青素、刺五加提取物和茶多酚均显示了对红细胞氧化损伤的拮抗作用,其中葡萄籽原花青素的作用最强。结论:TPP对红细胞氧化损伤具有很好的拮抗作用,是一种有价值的中药复方。
The aim of this study was to investigate the protective effects of compound tianpupian（TPP） and its compositions against oxidative damage in mouse erythrocytes.The protective effect of TPP and its compositions against the red cell hemolysis induced by H2O2 or auto-oxidation were observed by scanning electron microscopy and spectrophotomety.The result indicated that compound TPP and all of its four components including extract of Rhodiola sachalinensis,Grape Seed Extract proanthocyanidins,Acanthopanax senticosus extract,and tea polyphenols had significant inhibitory activities for the oxidative damage of mouse erythrocytes,out of which the Grape seed extract proanthocyanidins showed the maximal protective effect.It is concluded that compound TPP can protect erythrocytes against oxidative stress and can be used as a valuable Chinese traditional medicine.
出处
《中国实验血液学杂志》
CAS
CSCD
2011年第1期215-218,共4页
Journal of Experimental Hematology
基金
国家科技重大专项(编号2010ZX9102-204)
国家自然科学基金(编号81072914)
全军医药卫生科研基金课题(编号06MA265)
关键词
复方天葡片
氧化损伤
红细胞
compound tianpupian
oxidative damage
mouse erythrocyte
