摘要
目的评价奥沙利铂联合氟尿嘧啶5-FU、亚叶酸钙CF治疗老年Ⅲ期结肠癌(术后)的临床疗效及不良反应。方法 10例老年Ⅲ期结肠癌均为术后采用奥沙利铂联合氟尿嘧啶5-FU、亚叶酸钙CF(FOLFOX4方案)化疗,至少6个周期评价疗效。结果所有患者均可评价疗效和不良反应,其中CR2例、PR5例、SD3例、PD0例,总有效率达70.0%。主要的不良反应为骨髓抑制、消化道反应、神经毒性(主要是感觉神经毒性),毒副反应均可耐受。结论奥沙利铂联合氟尿嘧啶5-FU、亚叶酸钙CF(FOLFOX4方案)治疗老年Ⅲ期结肠癌(术后)有效率较高,不良反应可耐受。
Objective To evaluate the clinical effect and adverse reaction of Oxaliplatin combined with 5-FU, CF for the treatment of stage Ⅲ colon cancer in eldly patients. Methods 10 eldly patients with stage Ⅲ colon cancer were given the therapy of Oxaliplatin combiened with 5-FU, CF after surgery, the clinical effect was evaluated after at least 6 cycles. Results＇ All the patients were evaluated the effect and adverse reaction, among whom CR： 2 cases, PR： 5 cases, SD： 3 cases, PD： 0 case, the total effective rate was 70.0%. The main adverse reaction were myelosuppression, gastrointestinal reactions, neurotoxicity （mainly sensory nerve toxicity）, all the cases could endure the main adverse reaction. Conclusion The effective rate of FOLFOX4 program for the treatment of stage Ⅲ colon cancer in eldly patients is high, the adverse reaction can be endured.
出处
《临床医学工程》
2011年第3期345-346,共2页
Clinical Medicine & Engineering
关键词
Ⅲ期结肠癌
老年
奥沙利铂
联合化疗
Stage Ⅲ colon cancer
Eldly patients
Oxaliplatin
Combination chemotherapy
