摘要
目的:探讨奥沙利铂联合亚叶酸钙和5-氟尿嘧啶治疗结肠癌的有效性及对细胞因子水平的影响。方法:选取2013年1月-2015年2月于本院收治的晚期结肠癌患者78例作为研究对象,采用随机数字表法将其分为对照组和观察组,每组39例。对照组给予亚叶酸钙及5-氟尿嘧啶联合治疗,观察组在进行联合治疗的基础上加用奥沙利铂,8周为1个疗程,2个疗程后比较两组治疗总有效率和不良反应发生率,应用ELISA法检测血清肿瘤坏死因子及白细胞介素水平。结果:观察组治疗总有效率高于对照组,比较差异有统计学意义(P<0.05);两组不良反应发生率比较差异无统计学意义(P>0.05);治疗后两组血清肿瘤坏死因子-α(TNF-α)、白细胞介素-2(IL-2)水平均高于治疗前,白细胞介素-6(IL-6)血清水平低于治疗前,且观察组IL-6、IL-2及TNF-α水平均优于对照组,比较差异均有统计学意义(P<0.05)。结论:奥沙利铂联合化疗治疗晚期结肠癌疗效明确,并可有效改善患者免疫功能,值得临床推广应用。
Objective：To investigate the therapeutic efficacy and safety of Oxaliplatin combined with Calcium Folinate and 5-FU in the treatment of colon carcinoma and its influence on the levels of cytokines in serum.Method：A total of 79 patients with advanced stage colon carcinoma in our hospital from January 2013 to February 2015 were selected and randomly divided into the observation group and the control group,each group had 38 cases.The control group was treated by Calcium Folinate and 5-FU,while the observation group was treated by Oxaliplatin on the basis of the control group.The effective rate,incidence of adverse reaction and the serum levels of tumor necrosis and interleukin of the two groups were compared.Result：The total effective rate of the observation group was significantly better than that of the control group,the difference was statistically significant（P〈0.05）.The difference in the incidence of adverse reactions was not statistically significant（P〈0.05）.After treatment,the serum levels of TNF-α and IL-2 of the two groups were higher than those before treatment,the serum level of IL-6 was lower than that before treatment,the serum levels of TNF-α,IL-6 and IL-2 of the observation group were better than those of the control group,the differences were all statistically significant（P〈0.05）.Conclusion：Oxaliplatin combined with chemotherapy in the treatment of colon carcinoma can achieve an clear effect and it can improve patients＇ immunologic function.It is worthy of clinical application.
出处
《中国医学创新》
CAS
2015年第33期4-7,共4页
Medical Innovation of China
基金
2014年国家自然科学基金资助(81402025)
关键词
结肠癌
TNF-Α
IL-2
IL-6
奥沙利铂
Colon cancer
Tumor necrosis factor-α
Interleukin 2
Interleukin 6
Oxaliplatin
