摘要
目的研究人类表皮生长因子受体-2（HER-2）在乳腺癌中的表达及其与肿瘤坏死因子-α（TNF—α）的相关性。方法HER-2是武汉大学中南医院乳腺癌患者常规检测项目。我们采用免疫组化SABC法检测112例原发性乳腺癌组织中TNF-α的表达，分析HER-2在乳腺癌中的表达、HER-2与乳腺癌临床病理特征的关系以及HER-2和TNF—α的相关性。结果（1）乳腺癌中HER-2的阳性表达率为35．71％（40／112），其中在97例浸润性导管癌中的阳性表达率为35．05％（34／97），在浸润性小叶癌中的阳性表达率为33．33％（2／6），在黏液腺癌中的阳性表达率为25．00％（1／4），在导管内癌中的阳性表达率为50．00％（2／4），1例小叶原位癌为HER-2阳性。HER-2在各类型乳腺癌中的差异无统计学意义（P〉0．05）。（2）HER-2在乳腺癌中的表达与TNM分期、年龄、初潮年龄、是否绝经、孕次、产次、肿瘤家族史均无相关性（P均〉0．05）。（3）HER-2阴性时TNF—α的阳性率为23．61％（17／72），HER-2阳性时TNF-α的阳性率为52．50％（21／40）。HER-2和TNF-α在乳腺癌中的表达有显著正相关性（r=0．881，P〈0．05）。结论HER-2与TNF-α在乳腺癌中的表达有显著正相关性，具体机制有待更多研究。
Objective To determine the expression of Human Epidermal Growth Factor Receptor 2 （HER-2） in breast cancer and its correlation with Tumor Necrosis Factor-α （TNF-α）. Methods We used SABC method to detect the expression of HER-2 and TNF-α in 112 cases of primary breast cancer, and analyzed the association of HER-2 expression with clinicopathological features and TNF-α expression. Results The positive expression rate of HER-2 in breast cancer was 35.71% （40/112） , of which, the expression rate was 35.05% （34/97） in 97 invasive tubic breast cancer, and 33.33% （2/6） in invasive lobular breast cancer, 25.00% （1/4） in mucinous carcinoma, and 50. 00% （2/4） in intraductal carcinoma. There was no significant correlation between HER-2 and any clinieopathological features of primary breast cancer （ P 〉 0. 05 ） . The expression of HER-2 in breast cancer had no signiciant association with TNM stage, age, age of menarche, menopause, gravidity, parity and family history of cancer （ Ps 〉 0.05 ） , The positive rate of TNF-α was 23.61% （17/72） when HER-2 was negative, whereas the positive rate of TNF-α was 52. 50% （21/40） when HER-2 was positive. The expression of HER-2 was signiciantly positively correlated with the expression of TNF-α （r = 0. 881, P 〈 0. 05 ）. Conclusion HER-2 expression had a positive correlation with TNF-α in breast cancer, but the specific mechanism is still unclear.
出处
《中国综合临床》
2011年第3期239-241,共3页
Clinical Medicine of China
基金
国家自然科学基金资助项目（30901308）
