摘要
目的探讨10kd低分子量尿蛋白在原发性肾小球疾病患者中临床病理的意义。方法对本院120例临床、病理证实为原发性肾小球疾病患者。检测尿常规、24h尿蛋白定量、血肌酐等，计算肾小球滤过率；KatafuchiR半定量标准对肾小管间质病理进行评分；薄层十二烷基硫酸钠-聚丙烯酰胺凝胶电泳（SDS—PAGE）检测患者尿蛋白分子量。以是否含有10kd低分子量尿蛋白分为2组，比较分析其临床病理差异。结果含有10kd低分子量尿蛋白患者38例，同82例不含10kd尿蛋白患者相比，血肌酐较高[（185．63±123．29）μmol／LVS（84．92±60．31）μmol／L，P〉0．05]，肾小球滤过率较低[（40．6±18．3）ml·（min·1．73m^2）^-1VS（79．8±30．6）ml·（min·1．73m^2）^-1，P〉0．05]，肾间质病理评分较高（5．9±3．7VS3．3±2．1，P〉0．05）；两组间差异有统计学意义。结论出现10kd低分子量尿蛋白患者临床病理表现均较严重，预后较差。10kd低分子量尿蛋白对患者慢性肾脏病的进展起重要作用。
Objectives To investigate the clinicopatholngic significance of urinary protein of 10kd low molecular weight in primary glomerulopathy. Methods The serum ereatinine levels（Scr） ,24h urine protein quantitation and glomerular filtration rate（GFR） were measured and the scores of tubulointerstitial lesions were examined by Katafuchi R standard in 120 biopsy - proven cases of primary glomerulopathy patients. Urine protein was analyzed by thin - membrane sodium dodecyl sulphat - polyacrylamide gel electrophoresis （ SDS - PAGE ）. The clinicopatbologic characteristics between the patients with and without urinary protein of 10kd low molecular weight were compared. Results Amongst the 120 patients studied,38 had urinary protein of 10kd low molecular weight, compared with other 82 cases without lOkd urinary protein,the Scr was higher [ （ 185.63 ± 123.29） μmol/L vs （ 84.92 ± 60.31 ） p.mol/L,P 〉0.05] ,GFR was lower[ （40.6 ± 18.3）ml · （min · 1.73m^2）^ -1 vs（79.8 ±30.6）ml · （min · 1. 73m^2 ） ^- 1 vs （79.8± 30.6） ml/min/1. 73m^2, p 〉 0.051, the seore of tubulointerstitial lesions was higher（5.9 ± 3. 7 vs 3.3 ± 2.1, p 〉 0.05 ）, the differences had statistieal significance. Conclusions The patients with urinary protein of 10kd have a poorer prognosis than those patients without. Urinary protein of 10kd low molecular weight plays an important role in the progression of ehronie kidney disease.
出处
《国际泌尿系统杂志》
2011年第2期164-166,共3页
International Journal of Urology and Nephrology
基金
厦门市卫生局资助项目（编号：WZK0612）
关键词
肾小球肾炎
蛋白尿
Glomerulonephritis
Proteinuria
