摘要
目的:比较长托宁和阿托品对不同中毒程度、不同年龄急性有机磷杀虫药中毒的疗效及经济学效果。方法:387例患者随机分为长托宁组194例和阿托品组193例,按中毒程度给予不同剂量的长托宁和阿托品,观察疗效并进行成本-效果分析。结果:长托宁与阿托品组轻、中、重度中毒治愈率分别为100%与100%、100%与97.9%、91.5%与83.6%;成本分别为2071元与1282元、4270元与2062元、9015元与8611元;成本-效果比分别为20.7与12.8、42.7与21.1、98.5与103.0;长托宁组相对于阿托品组的增量成本-效果比分别为无比较意义、1036.6、50.8。60岁以上的老年患者治愈率分别为88.4%与66.7%(P<0.05)。结论:轻、中度有机磷杀虫药中毒首选阿托品治疗,重度及老年患者首选长托宁治疗。
To compare therapeutic efficacy and economic effect of penehyclidine hydrochloride （PHC） and atropin in the treatment of acute organophosphorus poisoning in different poisoning degree and different age groups. METHODS： A total of 387 patients were divided into PHC group （194 cases） and atropin group （193 cases）. Both groups were treated with the appropriate dose of PHC and atropin according to the degrees of poisoning. The clinical efficacy and cost-effectiveness of 2 groups were studied. RESULTS： The cure rates of mild, moderate and severe poisoning in PHC group were 100%, 100%, 91.5%, in at- ropin group were 100%, 97.9% and 83.6%. The costs of PHC group were 2 071 yuan, 4 270 yuan, 9 015 yuan, and those of atro- pin group were 1 282 yuan, 2 062 yuan, 8 611 yuan. The cost-effectiveness ratio of PHC group was 20.7, 42.7, 98.5, and those of atropin group were 12.8, 21.1, 103.0. There was no significant difference in incremental cost-effective ratio between PHC group （1 036.6） and atropin group （50.8）. The cure rates of elderly patients aged more than 60 years were 88.4% and 66.7% （P〈0.05）. CONCLUSION： Atropin is the first choice for mild and moderate poisoning. As for the severe poisoning and elderly patients, the treatment of PHC is better than atropin.
出处
《中国药房》
CAS
CSCD
北大核心
2011年第12期1106-1108,共3页
China Pharmacy
关键词
长托宁
阿托品
有机磷中毒
成本.效果分析
Penehyclidine hydrochloride （PHC）
Atropin
Organophosphorus poisoning
Cost-effectiveness analysis
