摘要
泌尿道感染(Urinary tract infections,UTIs)是世界范围内严重的公共卫生问题。尿道致病性大肠杆菌(Uropathogenic Escherichia coli,UPEC)是引发UTIs的首要致病菌。I型菌毛是UPEC重要的毒力因子,在UPEC中分布广泛,介导其在泌尿道的粘附、侵入和定植。该文对UPECⅠ型菌毛的结构、装配和毒力机制进行综述。
Urinary tract infections are serious public health problem worldwide. Strains of uropathogenic Escherichia coli （UPEC）are the primary cause of urinary tract infections. Type 1 pilus of UPEC is a very important virulence factor,widely distributed in UPEC,and mediates its adhesion, invasion and colonization in the urinary tract. The structure, assembly and virulence mechanism of type 1 pilus were reviewed in this paper.
出处
《中国慢性病预防与控制》
CAS
北大核心
2011年第1期101-103,共3页
Chinese Journal of Prevention and Control of Chronic Diseases
基金
国家自然科学基金资助项目(81000707)
关键词
泌尿道感染
尿道致病性大肠杆菌
I型菌毛
Urinary tract infections
Uropathogenic Escherichia coli
Type 1 pilus
