摘要
目的评价粉尘螨特异性免疫治疗联合规范化防治在儿童支气管哮喘(哮喘)控制中的作用。方法回顾性分析2005年4月-2010年6月随访的95例哮喘合并变应性鼻炎患儿。将其分为治疗组(54例)和对照组(41例)。治疗组采用特异性免疫治疗联合规范化防治,对照组仅采用吸入激素为主的哮喘防治方案。评价2组治疗前后哮喘发作及控制情况,了解治疗前后呼吸道感染次数及平均持续时间,比较治疗前后汉化版儿童哮喘控制测试量表(Ch-CACT)及最大呼气流量(PEF)测试结果,尤其是2组患儿在哮喘的高发季节Ch-CACT、PEF测试结果及病情控制情况。应用SPSS 15.0统计软件分析数据。结果治疗组治疗后1 a哮喘急性发作次数较对照组减少,病情程度减轻,控制情况更理想。治疗后1 a,2组患儿Ch-CACT及PEF结果均较治疗前改善,差异有统计学意义。但在治疗后1 a高发季节,对照组Ch-CACT及PEF测试结果均下降,与治疗结束后监测结果比较差异有统计学意义;而治疗组治疗结束时与治疗后1 a,高发季节Ch-CACT及PEF结果比较差异无统计学意义。治疗后1 a,2组患儿呼吸道感染次数均较治疗前减少,尤以治疗组减少明显,且治疗组呼吸道感染平均持续时间也明显减少,差异均有统计学意义。治疗组吸入激素量显著减少,部分病例甚至停用吸入激素也可达到病情控制的目的。结论特异性免疫治疗联合规范化防治能更有效地减少哮喘发作次数,减轻哮喘发作程度,在高发季节病情更趋稳定。特异性免疫治疗能明显增强患者对呼吸道感染的抵抗力,从而达到更好地控制哮喘病情的目的。
Objective To evaluate the effect of dust mite allergen-specific immunotherapy combined with standardized management on prevention and therapeutic effect in children with asthma.Methods Ninety-five children with established diagnosis of allergic asthma to dust mite were enrolled in this study from Apr.2005 to Jun.2010,of whom 54 children received treatment with specific immunotherapy（SIT） combined with standardized management（treatment group）for 2-3 years,and the other 41 cases served as the control group,who received only standardized management（inhaled corticosteroids） at the same time.The clinical symptom and acute episode of the asthmatic children,peak expiratory flow（PEF） and children asthma control test（Ch-CACT）,the frequency of respiratory tract infection were detected before and after the treatment,especially the season with high attack rate in 1 year after the treatment.The data were analyzed by SPSS 15.0 software.Results Compared with control group,the frequency of acute episode,the degree of stable phase of asthma,the dose of inhaled corticosteroids in treatment group after treatment for 1 year were significantly decreased.The PEF and Ch-CACT in both groups were obviously improved and the frequency of respiratory tract infection in both groups after treatment for 1 year were obviously decreased.But the PEF and Ch-CACT in control group were obviously dropped in the season with high attack rate after treatment for 1 year and the average duration of respiratory tract infection in control group were obviously prolonged.Conclusions The dust mite allergen-specific immunotherapy combined with standar-dized management can obviously reduce the frequency and degree of acute episode of asthma,improve the pulmonary function of asthmatic children,decrease the the frequency and the average duration of respiratory tract infection.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2011年第4期241-243,共3页
Journal of Applied Clinical Pediatrics
基金
上海市科委基金(08411953100)
上海市卫生局基金(2009237)
关键词
哮喘
粉尘螨
特异性免疫治疗
疗效
儿童
asthma
dust mite
specific immunotherapy
therapeutic efficacy
child
