摘要
目的建立羟基红花黄色素A含量测定的方法,探讨红花注射液在0.9%氯化钠注射液、5%葡萄糖注射液中的稳定性及配伍。方法在配伍后0,2,4,6,8,24 h取样,采用高效液相法测定红花注射液与0.9%氯化钠注射液、5%葡萄糖注射液配伍液体内羟基红花黄色素A的含量,同时考察配伍液的pH值、微粒。结果室温条件下(25℃)24 h内各配伍液的pH值、羟基红花黄色素A含量均无明显变化;微粒数有显著变化,随着剂量的增加和时间的延长,微粒数随之增多。结论红花注射液与以上2种常用输液的配伍液在4 h内稳定。
Objective To establish a method for determining the contents of hydroxysafflor yellow A,and explore the stability and compatibility of safflower injection in 0.9% sodium chloride injection or 5% glucose injection.Methods At 0,2,4,6,8,24 h,the contents of hydroxysafflor yellow A in two mixtures of safflower injection and 0.9% sodium chloride injection or 5% glucose injection were determined by HPLC,and the pH value and microparticles were also investigated.Results There was no significant change in the pH values and contents of hydroxysafflor yellow A in 24 h at room temperature（25 ℃）after compatibility.However microparticles had significant changes,and increased with the increase of dose and time.Conclusion The stability is good within 4 h in two different infusions of safflower injection.
出处
《山西医科大学学报》
CAS
2011年第2期123-125,共3页
Journal of Shanxi Medical University
关键词
红花注射液
羟基红花黄色素A
配伍
稳定性
safflower injection
hydroxysafflor yellow A
compatibility
stability
