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CTGF表达在食管癌术后吻合口狭窄中的作用及机制

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摘要 目的探讨结缔组织生长因子(CTGF)表达在食管癌术后吻合口狭窄中的作用及机制。方法根据40例食管癌患者的术后吻合口直径,分为吻合口狭窄组(A组)、无吻合口狭窄组(B组)各20例,检测两组食管癌切缘及术后吻合口瘢痕中的CTGF表达。结果与B组比较,A组食管切缘及术后吻合口瘢痕中的CTGF表达率均明显高于B组(P均<0.01)。结论食管癌术后吻合口狭窄患者的食管切缘及吻合口瘢痕中的CTGF表达率均明显高于无狭窄者,提示食管切缘处CTGF高表达对患者术后吻合口狭窄的高发生率有一定预测意义;CTGF高表达可能是食管癌术后吻合口瘢痕组织过度形成及导致吻合口狭窄的重要分子机制。
出处 《山东医药》 CAS 北大核心 2011年第5期90-91,共2页 Shandong Medical Journal
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