摘要
目的:探讨尼莫地平对卒中后抑郁(Post-strok depression,PSD)患者认知功能的改善作用。方法:将267例卒中后抑郁患者随机分为两组,常规治疗原发病、康复训练及赛乐特片20 mg/d,治疗组在此基础上同时合并使用尼莫同片30 mg,3次/d,各组患者观察治疗,并随访至12周末。在治疗前及治疗后第4周、8周1、2周末进行蒙特利尔认知评估量表(Montreal Cognitive Assessment,MoCA)及HAMILTON抑郁量表评分。结果:两组患者治疗前采用MOCA评分及HAMILTON抑郁量表评分经t检验P>0.05,差异无统计学意义;治疗后4周8、周、12周治疗组与对照组以上各种评分比较经t检验P<0.05,差异有统计学意义。结论:尼莫同能有效改善轻、中度卒中后抑郁患者的认知功能。
Objective To Nimodipine（trade names：Nimotop） in patients with poststroke depression on cognitive function improvement.Methods 267 cases of patients with poststroke depression were randomly divided into two groups,conventional treatment of the primary disease,rehabilitation training and Seroxat Tablets 20 mg/d,the treatment group at the same time on the basis of a combination of nimodipine tablets with 30 mg,3 times/d,each group of patients with treatment and follow-up to 12 over the weekend.Pre-treatment and treatment in the first 4 weeks,8 weeks and 12 weekends in Montreal Cognitive Assessment Scale（Montreal Cognitive Assessment,MoCA） and HAMILTON Depression Scale score.Results Two groups of patients before treatment using MOCA Depression Scale score and HAMILTON score by t test P0.05,no significant difference;4 weeks after treatment,8 weeks,12 weeks of treatment group and above the control group by t test score comparison P0.05,significant difference.Conclusion Nimotop can be effective in improving mild to moderate post-stroke depression in patients with cognitive function.
出处
《吉林医学》
CAS
2011年第5期878-880,共3页
Jilin Medical Journal
