摘要
目的探讨阻塞性睡眠呼吸暂停低通气综合征(obstructive sleep apnea-hypopnea syndrome,OSAHS)对急性脑梗死患者认知功能的影响,为血管性认知障碍的早期防治提供依据。方法对经头颅CT或MRI证实的急性脑梗死患者(41例,男21例,女20例)均进行多导睡眠图(polysomnogram,PSG)、简易智能筛查(mini-mental state examination,MMSE)、画钟试验(clock drawing task,CDT)、词语流畅试验(verbal fluency test,VFT)、听觉事件相关电位(P300)检测。结果 41例患者完成所有检查。MMSE评分<27分者27例(65.85%),CDT评分<4分者19例(46.34%),VFT评分<15分者16例(39.02%)。依PSG检查结果分为OSAHS组(21例),非OSAHS组(20例)。OSAHS组MMSE、CDT分值低于非OSAHS组,两组比较无统计学差异(P>0.05),亚组分析显示中-重度OSAHS组MMSE、CDT得分为23.67±5.12,2.67±1.53,非OSAHS组为24.85±3.15,3.1±1.2,两组比较有统计学差异(P<0.05)。P300检查显示与非OSAHS组比较OSAHS组FZ、CZ、PZ潜伏期明显延长,FZ、CZ潜伏期比较有统计学差异(P<0.05),中重度OSAHS组较非OSAHS组PZ潜伏期显著延长(P<0.005)。各组P300的波幅无统计学差异(P>0.05)。结论 OSAHS可加重急性脑梗死者的认知功能障碍,且与其严重程度相关。P300检查较MMSE、CDT更敏感。
Objective To investigate the influence of obstructive sleep apnoea/hypopnoea syndrome （OSAHS） on cognition of patients with acute ischemic stroke.Methods The patients with acute ischemic stroke （21 male and 20 female） were examined by PSG,auditory P300,MMSE,CDT and VFT,respectively.Results The scores of MMSE was less than twenty-seven in Twenty-seven patient （65.85%）; the scores of CDT was less than four （46.34%） in nineteen patients and the scores of VFT was less than fifteen （39.02%） in sixteen patients.Forty-one patients were divided to two groups：the OSAHS group （n=21） and the non-OSAHS group （n=21） according to the results of PSG.The scores of MMSE and CDT in the OSAHS group were smaller compared with the non-OSAHS group.There were no significant differences in the scores of MMSE,CDT and VFT between the two groups （P0.05）.But the scores of MMSE,CDT in moderate-severe degree OSAHS group were smaller compared with non-OSAHS groups （23.67±5.12,2.67±1.53 vs 24.85±3.15,3.1±1.2 （P0.05）.P300 lantency of Fz and Cz in the OSAHS group was significantly longer than that in non-OSAHS groups （P0.05）.P300 lantency of Pz in moderate-severe degree OSAHS group was longer than that in non-OSAHS groups （P0.005）.P300 Amplitude did not change significantly.Conclusions OSAHS can worsen cognitive decline in patients with acute ischemic stroke and cognitive impairment in the patients is associated with the severity of OSAHS.
出处
《中国神经精神疾病杂志》
CAS
CSCD
北大核心
2010年第10期590-593,共4页
Chinese Journal of Nervous and Mental Diseases
基金
江西省卫生厅科技项目(编号:20070619)
