摘要
肝脏具有极强的再生能力,与其作为体内最重要的解毒器官并常被多种毒素损伤相适应.肝再生研究一直是再生医学研究领域的热点,其机制已得到深入阐明,但仍有一些热点问题尚存在广泛争议,例如,哪些因素决定了是肝细胞还是干细胞作为不同性质肝损伤后肝再生的主要细胞学基础;肝再生的启动因素有哪些;肝再生过程中肝功能是如何维持和代偿的;肝再生终止信号,以及肝再生结束后肝小叶如何进行重构.本文将就这些尚存争议或尚未阐明的问题进行阐述.
The liver is an interesting organ with unusual regenerative capacity to adapt its role as the main detoxifying organ in the body that is likely to be injured by various toxins.Many aspects of the signaling mechanisms involved in hepatic regeneration have been clarified,however,sev-eral central questions are still in debate.The pur-pose of this review is to focus on the areas still not well understood,including the factors that determine whether hepatocytes or liver progeni-tor cells should be evoked for proliferation after various injuries,the factors that initiate liver regeneration,the mechanisms by which the liver maintains and compensates its function during regeneration,the signals that lead to proper ter-mination of liver regeneration,and the process of lobular remodeling after regeneration.
出处
《世界华人消化杂志》
CAS
北大核心
2010年第34期3611-3615,共5页
World Chinese Journal of Digestology
基金
国家自然科学基金资助项目
No.30870983~~
关键词
肝再生
肝细胞
热点问题
Liver regeneration
Hepatocyte
Central question
