摘要
目的探讨复合性淋巴瘤(CL)的病理组织学特征、诊断与发病机制。方法应用光镜观察及免疫组化染色对3例少见类型的CL进行临床病理学分析。结果 3例CL中2例为转化的弥漫性大B细胞淋巴瘤(DLBCL),其中1例由慢性淋巴细胞白血病/小淋巴细胞淋巴瘤(CLL/SLL)转化为DLBCL(Richter综合征);另1例为结节性淋巴细胞为主型霍奇金淋巴瘤(NLPHL)转化为DLBCL;第3例为原发性纵隔大B细胞淋巴瘤(PMBCL)合并经典型霍奇金淋巴瘤(cHL)。结论 CL是一种特殊类型淋巴瘤。发生转化后的Richter综合征预后差;NLPHL预后较好,但可进展为侵袭性淋巴瘤。非霍奇金淋巴瘤(NHL)与HL的关系密切。
Objective To study the clinical and pathologic features,diagnosis and pathogenesis of composite lymphoma（CL）.Methods Three rare cases of CL were studied by microscopy and immunohistochemistry,with review of related literature.Results Two cases of the three CLs were transformed into diffuse large B cell lymphomas（DLBCL）,which were from chronic lymphocytic leukemia/small lymphocytic lymphoma（CLL/SLL）（also called as Richter syndrome） and nodular lymphocyte predominant Hodgkin lymphoma（NLPHL）,respectively.The third case was composite primary mediastinal large B cell lymphoma and classical Hodgkin lymphoma.Conclusion CL is a distinct entity of lymphoma.The prognosis is poor when CLL/SLL transforms into Richter syndrome.The NLPHL has good prognosis,however,it can progress into an aggressive lymphoma.The relation between non-Hodgkin lymphoma（NHL） and HL is close.
出处
《诊断病理学杂志》
CSCD
2010年第6期405-410,共6页
Chinese Journal of Diagnostic Pathology
