摘要
目的：探讨多种因素对AID治疗结局的影响。方法：回顾2008年11月-2010年5月在生殖中心实施AID助孕治疗的418名妇女639个治疗周期的病例,综合分析不孕妇女的年龄、输卵管情况、治疗周期、促排卵用药及授精次数等因素对AID治疗妊娠结局的影响。结果：AID周期妊娠率为34.90%（223/639）,例数妊娠率为53.34%（223/418）。临床妊娠率与女方年龄、是否合并输卵管因素、授精与排卵时间等有一定关系。排卵前后短时内单次授精的平均妊娠率反而高于排卵前后双次授精。639个AID周期中,随治疗周期的增加累计妊娠率随之增高,但周期妊娠率下降,第1-3周期临床妊娠率依次为37.08%、31.98%、21.95%。AID促排卵周期妊娠率与自然周期无差异（34.02%、35.63%）。结论：不孕妇女的年龄、输卵管情况及授精时机的掌握是影响供精人工授精成功率的重要因素。对超过3周期仍不孕者,可考虑改行供精体外授精-胚胎移植进行助孕。
Objective：To explore the effect of multiple factors on outcomes of artificial insemination with donor semen（AID）.Methods：639 cycles of 418 women receiving AID in the hospital from November 2008 to May 2010 were analyzed retrospectively;the effects of age of infertile women,oviduct situation,treatment cycle,drug use of ovulation induction and times of insemination on pregnancy outcomes of cases receiving AID were analyzed comprehensively.Results：The pregnancy rate per cycle was 34.90%（223/639）,the case pregnancy rate was 53.34%（223/418）;clinical pregnancy rate in a way was related to female age,combining with oviduct factors or not,insemination and ovulation time;the average pregnancy rate of single insemination within short time before and after ovulation was significantly higher than that of double insemination;in 639 cycles,the cumulative pregnancy rate increased with treatment cycle,but the cycle pregnancy rate decreased,the clinical pregnancy rates from the first to third cycle were 37.08%,31.98% and 21.95%,respectively;there was no significant difference in pregnancy rate between ovulation induction cycle and natural cycle（34.02%,35.63%）.Conclusion：The age of infertile women,oviduct situation and opportunity of insemination are important effect factors of success rate of artificial insemination;for the cases without pregnancy after treated more than 3 cycles,in vitro fertilization-embryo transfer is recommended.
出处
《中国妇幼保健》
CAS
北大核心
2011年第5期711-714,共4页
Maternal and Child Health Care of China
关键词
供精人工授精
无精子症
临床妊娠率
Artificial insemination with donor semen
Azoospermia
Clinical pregnancy rate
