摘要
目的：进一步明确维生素Ｄ 和维生素Ｋ 与肾结石的关系。方法：健康成年雄性ＳＤ大鼠３６ 只随机分成６组，即对照组、单纯成石组、维生素Ｄ组、诱石剂＋ 维生素Ｄ 组、维生素Ｋ 组和诱石剂＋ 维生素Ｋ组，测定肾脏骨桥蛋白（ｏｓｔｅｏｐｏｎｔｉｎ， ＯＰＮ） ｍＲＮＡ 的表达量和尿晶体成分的浓度。结果：维生素Ｄ 和维生素Ｋ 均可促进肾脏表达ＯＰＮ ｍＲＮＡ；维生素Ｄ可升高尿钙，维生素Ｋ则抑制尿草酸的分泌，诱石剂有降低尿镁和柠檬酸的作用。结论：维生素Ｄ过多可促进肾结石形成，而维生素Ｋ 有抑制结石形成的作用。
Objective: To clarify the relationship between kidney calculi and vitamin D 3 as well as vitamin K 3 further. Methods: 36 adult male SD rats were randomized into control group, stone forming group, vitamin D 3 group,vitamin D 3 with stone forming group, vitamin K 3 group and vitamin K 3 with stone forming group. The urine was collected on day 7, and osteopontin(OPN) mRNA of kidneys and the concentration of the crystal components in urine were detected. Results: Vitamin D 3 and vitamin K 3 could enhance the expression of OPN mRNA in rat kidneys of stone model. Vitamin D 3 could increase the excretion of oxalate in urine, while vitamin K 3 inhibited the excretion of oxalate. Stone inducing agents could inhibit the excretion of magnesium and citrate in urine. Conclusion: The results indicate that vitamin D 3 may promote stone formation, whereas vitamin K 3 may inhibit this process.
出处
《北京医科大学学报》
CSCD
1999年第5期429-431,共3页
Journal of Peking University(Health Sciences)
基金
国家自然科学基金
关键词
维生素D
维生素K
药理学
骨桥蛋白
mRNA
肾结石
Vitamin D/pharmacol Vitamin K/pharmacol Osteopontin ☆ RNA, messenger/metab Kidney calculi/metab
