摘要
目的进一步明确维生素D和维生素K与肾结石的关系，探讨成石机制。方法将健康成年雄性SD大鼠24只随机分成4组，即对照组、诱石组、维生素D组和维生素K组，收集第1、3、7天约24小时尿，测定尿晶体成分的浓度。结果维生素D组尿钙和草酸明显高于对照组和诱石组，尿镁和柠檬酸显著降低（P＜0．05）。维生素K组尿草酸明显低于诱石组（P＜0．05）。结论维生素D可能通过多种机制促进肾结石形成，而维生素K有抑制结石形成的作用。
Objective To investigate the relationship between kidney calculi and Vitamin D3 aswell as Vitamin K. Methods Twenty-four adult male SD rats were randomly divided into 4 groups(control group, stone-inducing group, Vitamin D3 group and Vitamin K group). The urine were collected at day 1, 3 and 7, and the crystal components in urine were detected. Results As compared withcontrol group and stone-lnducing group, the calcium and oxalate in urine were increased significantly inVitamin D group, while the magnesium and citrate were decreased significantly (P<0. 05). The oxalate in urine of Vitamin K group was decreased significantly as compared with that of stone-inducinggroup (P <0. 05). Conclusions Vitamin D may promote stone formation through various mechanisms, whereas Vitamin K could inhibit this process.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
1999年第3期240-241,共2页
Chinese Journal of Experimental Surgery
基金
国家自然科学基金!39670722
关键词
肾结石
维生素D
维生素K
动物模型
Kidney calculi, Vitamin D_3, Vitamin K, Animal model
