摘要
目的探讨儿童格林-巴利综合征（GBS）的危险因素。方法采用病例对照设计方法．对51例儿童GBS患者和51例对照儿童进行入户问卷调查，调查因素包括一般情况、发病诱因、家庭环境和个人卫生等方面。病例诊断根据临床症状、体征和神经电生理检查，并测定血清空肠弯曲菌IgG抗体。结果51例患儿中有45例（88．2％）来自农村。对例患儿于病前2～4周曾有前驱症状（72．5％）。既往脊髓灰质炎疫苗和乙型肝炎疫苗接种史的OR值分别为7.27和3.14，病前有受凉史以及到过河湖地区旅行史的OR值分别为13．75和12．20；饭前便后不洗手的OR值为6.15S;51例病例中有19例的血清空肠弯曲菌IgG抗体呈阳性，而对照组只3例限性，OR值为9.5。以上结果差异均有非常显著性。患儿血清空肠弯曲菌IgG抗体的吸光度均值（0.171）较对照儿童（0.063）明显升高．差异有显著性。结论儿童GBS发病与空肠弯曲菌感染及卫生状况不良有关。
Objective This study aimed at exploring the risk factors foHr Gnillain-Barre syndrome (GBS).Methods A case-control study design was used with 51 cases of GBS, diagnosed based on their symptoms, signsand elecbophysiolopcal examinations and exclusion of poiomyelihs and other acute flaccid Paralysis, and 51 controls matched on age. sex and resident village. Serum IgG antibodies specific for Campylobacter jejuni were determined for all the subjects by enyme-linked immunosorbent assay (EUSA) with a preparation of surface antigen ofC. jejuni C1 sttain isolated from the patients and prevalent in north China. Each case and contro were interviewedwith his/her ponts or guardians by a trained interviewer using an ad hoc questionnaire, including his / her demographic information, socioeconomic staus, onset of the illness, and potential risk factors in their environment andpersonal hygiene. Data were analyzed with SAS sofware release 6.04 in a microcomputer. Results GBS was associated with a few factors, such as residential areas (45 of the 51 cases liting in the rural areas, accounting for88. 2% of the total), polio and hepatitis B vaccine immunization before onset of the illness(with ORs of 7. 27 and3. 14, respetively), no hand washing afer defecation and before meals (with an OR of 6. 15 ) and getting cold andgoing to the river or lake site hefore onset of the illness(with ORs of 13. 75 and 12. 20, respectively ). Infectionwith Campylobacter jejuni asaseiated strongly with the illness (with an OR of 9. 5, P < 0.001 ). Thirty-five of the51 cases had precursor symptoms before onset of the illness (68. 6%). Comclusion It suggests that occurrence ofGBS may correlate to infection with Campylobacter jejum and poor personal hygiene in children.
出处
《中华预防医学杂志》
CAS
CSCD
北大核心
1999年第5期279-281,共3页
Chinese Journal of Preventive Medicine
