摘要
目的:对铁棒锤环糊精包合物进行抗炎、镇痛的初步药效学研究。方法:用β-CD包合铁棒锤,采用小鼠醋酸扭体及二甲苯致耳廓肿胀的动物实验方法。结果:铁棒锤包合物(1∶2)组能够减少小鼠扭体次数,包合物(1∶1)组能显著减轻二甲苯所致小耳廓肿胀程度,且实验过程中未出现小鼠中毒。结论:铁棒锤包合物具有抗炎镇痛作用且毒性较小。
Objective：To assess the anti-inflammation and analgesia of β-cyclodextrin inclusion compound of aconitum pendulum.Methods： The inclusion compound of menthol was prepared by β-CD.Two experimental techniques,including xylene-induced eartumefaction,twisting method to evaluate the pharmacodynamic effects of Aconiti.Results：The inclusion compoud of Aconiti（1∶2）group can significantly reduce the number of mice writhing,the inclusion compoud（1∶1）group can significantly reduce the extent of xylene-induced ear tumefaction swelling,and the mice do not appear toxic during the experiment.Conclusion：Aconiti has anti-inflammatory analgesic action and lower toxicity.
出处
《中医药学报》
CAS
2011年第1期15-16,共2页
Acta Chinese Medicine and Pharmacology
基金
教育部春晖计划项目(编号:Z2008-1-75021)
教育部科学技术研究重点项目(编号:210241)
关键词
铁棒锤
包合物
抗炎
镇痛
Aconitum pendulum
Inclusion compound
Anti-inflammation
Analgesia
