摘要
目的观察肺结核患者血清干扰素-γ（IFN-γ）及白细胞介素4（IL-4）水平与肺功能的相关性。方法75例肺结核患者（肺结核组）按病变程度分为重度25例（重度组）、中度25例（中度组）、轻度25例（轻度组），应用ELISA法检测各组肺结核患者和30例健康体检者（对照组）的外周血IFN-γ及IL-4水平并进行比较，同时检测肺结核组肺功能第1秒用力呼气量（FEV1）、第1秒用力呼气量占预计值的百分比（FEV1％）、最大用力呼气中段流量占预计值的百分比（MMEF％），并与IFN-γ及IL-4水平进行相关性分析。结果肺结核组IFN-γ，[（0．204±0．018）μg/L]及IL-4[（0．523±0．035）μg/L]水平与对照组比较差异均有统计学意义（t=7．685、6．374，均P〈0．05）；肺结核组中重度组、中度组及轻度组IFN-γ及IL-4水平比较差异有统计学意义（F=10．146、7．263，均P〈0．05）；肺结核中度组和重度组FEV1％、MMEF％与肺结核轻度组比较差异有统计学意义（均P〈0．05）；FEV1、FEV1％、MMEF％与IL-4水平呈显著负相关（r=-0．46、-0．43，均P〈0．05），与IFN-γ水平呈显著正相关（r=0．47、0．45，均P〈0．05）。结论肺结核发病与患者血清细胞因子水平有关；肺结核患者外周血清IFN-γ及IL-4水平可能对其肺功能有一定的影响。
Objective To explore the correlation of lung function and IFN-γ and IL-4 levels in peripheral blood in pulmonary tuberculosis patients. Methods The IFN-γ and IL-4 levels in peripheral blood of 75 pulmonary tuberculosis patients （ severe 25 cases, moderate 25 cases, and mild 25 cases） and 30 healthy volunteers were measured by ELISA. Meanwhile FEV1, FEV1% and MMEF% of lung function in 75 pulmonary tuberculosis patients were measured. Results The levels of IFN-γ[ （0. 204±0. 018） μg/L] and IL-4[ （0. 523±0. 035） μg/L] in peripheral blood were significantly different both between tuberculosis group and control group and among tuberculosis patients （ severe, moderate, and mild） （ t = 7. 685,6. 374, all P 〈 0. 05 ） ; FEV1, FEV1 %, and MMEF% of severe and moderate tuberculosis patients were signiflcandy lower than those of mild tuberculosis patients and normal reference value ; In tuberculosis patients, FEVI% and MMEF% were negatively related with IL-4 level in peripheral blood （r = -0.46, - 0. 43 ,all P 〈0. 05 ） ,also significantly positively related with the IFN-γ level in peripheral blood（ r = 0.47,0.45, all P 〈 0. 05）. Conclusion Pulmonary tuberculosis morbility may be due to cellular levels of patients. The IFN-γ and IL-4 levels in peripheral blood could affect the lung funetion of pulmonary tuberculosis patients.
出处
《中国基层医药》
CAS
2011年第3期301-302,共2页
Chinese Journal of Primary Medicine and Pharmacy
关键词
结核
肺
干扰素-Γ
白细胞介素-4
肺功能
Tuberculosis, pulmonary
Intefferon-γ
Interleukin-4
Lung function
