摘要
目的探讨骨折危险性评估工具（FRAX）评估类风湿关节炎（RA）患者骨质疏松性骨折风险的临床应用。方法选择本院就诊RA患者54例,采集患者骨折危险因素等临床资料,应用FRAX,使用或不使用骨密度（BMD）分别计算出未来10年髋部骨折及主要骨质疏松性骨折的概率,对结果进行分析比较。结果 54例RA患者,未使用BMD未来10年髋部骨折概率0~20%,主要骨质疏松性骨折概率2.5%~24%;使用BMD计算的骨折概率高于未使用BMD计算的骨折概率,差异有统计学意义（P〈0.01）;糖皮质激素疗程≥1年的患者使用BMD计算的骨折概率高于未使用BMD计算的骨折概率,差异有统计学意义（P〈0.01）;按骨折风险分组,中高危组与低危组在类风湿因子、抗ccp、c反应蛋白水平方面的差异有统计学意义（P〈0.01）。结论 FRAX可作为评估RA患者骨质疏松性骨折风险的一种切实可行的方法,若联合BMD可更准确地评估骨折风险。类风湿因子、抗ccp、C反应蛋白高水平的RA患者更应注重骨质疏松的防治。
Objective To analyze the osteoporotic fracture probability in RA patients with FRAX.Methods We selectd 54 RA patients in our hospital,measured femoral neck bone mineral density（BMD）in every patient with Duel energy X-ray absorptiomete,and recorded fracture risk factors of every patient.At last,we calculated hip fracture probability and osteoporotic fracture probability in the next 10 years with the FRAX.Results The hip fracture probability is 0～20%,the osteoporotic fracture probability is 2.5～24% in the next 10 years;the fracture probability with BMD is higher than the fracture probability without BMD,and the differences have statistical significance;if the patient used glucocorticoids more than one year,he should measure BMD in order to assess the fracture probability accurately;the difference have statistical significance in RF,anti-CCP and CRP levels between medium-high dangerous group and low-danger group.Conclusion The FRAX is a kind of feasible method to assess osteoporotic fracture risk in RA patients,It can assess fracture risk more accurately if using BMD,especially for the patients that used glucocorticoids more than one year.
出处
《实用临床医药杂志》
CAS
2011年第1期33-35,共3页
Journal of Clinical Medicine in Practice
