摘要
目的:检测抗环瓜氨酸肽(CCP)抗体在类风湿性关节炎(RA)中的阳性率,探讨抗CCP抗体检测在RA中的意义。方法:用ELISA方法检测30例RA,35例其他风湿性疾病,20例非风湿性疾病中的抗CCP抗体的分布。用免疫比浊法测定类风湿因子(RF),比较抗CCP抗体与RF的相关性。结果:30例RA病人中,抗CCP抗体的阳性率为73.33%。抗CCP抗体对RA的敏感性和特异性分别为73.33%和94.54%。RF的阳性率为76.67%。RF抗体对RA的敏感性和特异性分别为76.67%和80.0%。抗CCP抗体与RF之间呈正相关性。结论:抗CCP抗体对RA具有良好的敏感性和特异性,可视为RA新的血清学诊断指标,能用于RA的诊断。同时联合检测抗CCP抗体和RF有助于提高RA检测的敏感性和特异性。
Objective To evaluate anti-cylic citrullinated peptide antibody （anti-CCP antibody） positive rate and explore diagnostic value of anti- CCP antibody in patients with rheumatoid arthritis（RA）. Methods ELISA was used to assay anti-CCP antibodies in 30 patients with RA, 35 patients with other rheumatic disease and 20 normal controls respectively. Immune-nephelometry was applied to detect RF. Furthermore, compare the correlation between anti-CCP and RF. Results There was a 73.33% anti-CCP postive rate in patients with RA, its sensivity and specificity were 73.33% and 94.54% respectively. There was a 76.67% RF postive rate, its sensitivity and specificity were 76.67% and 80.0% respectively. Anti-CCP was associated with RF. Conclusion Anti-CCP presents a reasonable sensitivity with high specificity to RA and it is valuable to RA diagnosis. Combined measurement of anti- CCP is conducive to upgrade the sensitivity and specificity of RA diagnosis.
出处
《深圳中西医结合杂志》
2009年第4期224-226,共3页
Shenzhen Journal of Integrated Traditional Chinese and Western Medicine
基金
深圳市科技计划项目(200903036)
关键词
类风湿性关节炎
抗CCP抗体
类风湿因子
酶联免疫吸附测定
Rheumatoid Arthritis
Anti-cyclic Citrullinated Peptide Antibody
Rheumatoid Factor
Enzyme-Linked Immunosorbent Assay
