摘要
目的研究慢性阻塞性肺疾病(COPD)患者血清一氧化氮(NO)和肾上腺髓质素(ADM)的变化及意义。方法选择COPD急性加重期患者50例,分为Ⅰ级、Ⅱ级、Ⅲ级、Ⅳ级4组,应用硝酸还原酶法测定NO,酶联免疫吸附法测定肾上腺髓质素(ADM)水平,并记录动脉血气分析、肺功能等指标。同时与13例健康者进行对照。结果①COPD组血清NO较对照组显著降低,差异具有统计学意义(P<0.01),COPD组较对照组显著增高,差异具有统计学意义(P<0.01);②血清NO、ADM值随COPD分级增高而变化,且组间差异有统计学意义(P<0.05);③NO与FEV1、PaO2呈正相关,与PaCO2呈负相关;ADM与FEV1、PaO2呈负相关,与PaCO2呈正相关;NO与ADM呈负相关。结论 NO和ADM作为肺脏重要的舒血管因子,以不同的方式参与和影响了COPD的发生和发展。
Objective To research the changes and significance of nitric oxide（NO）and adrenomedullin（ADM）in patients with chronic obstructive pulmonary disease（COPD）. Methods 50 patients with COPD in exacerbated stage were divide into four groups according to diagnostic code（groupⅠ,Ⅱ,Ⅲ,Ⅳ）. The levels of blood serum NO and ADM in 50 cases of COPD and 13 healthy cases were detected. Arterial blood gas and pulmonary function were also measured. Results ①the blood serum NO levels of patients with COPD were significantly lower than those of healthy（P0.01）,the blood serum ADM levels of patients with COPD were significantly higher than those of healthy（P0.01）.②As the COPD group degreeⅠ, Ⅱ, Ⅲ, Ⅳ build up, the levels of blood serum NO and ADM were changed. The difference between those groups had significance（P0.05）.③The levels of NO had significantly positive correlation with PaO2 and FEV1 but negative correlation with PaCO2.The levels of ADM had significantly negative correlation with PaO2 and FEV1 but positive correlation with PaCO2.The levels of NO had significantly negative correlation with ADM. Conclusion As the important relaxing factor of the lung, NO and ADM play important roles in the generation and progress of COPD.
出处
《中国实用医药》
2011年第3期13-15,共3页
China Practical Medicine
关键词
慢性阻塞性肺疾病
一氧化氮
肾上腺髓质素
Chronic obstructive pulmonary disease
Nitric oxide
Adrenomedullin
