摘要
目的探讨重组人类基因促红细胞生成素（EPO）对早产儿脑损伤保护作用及临床疗效。方法将42例发生脑室周围白质软化（PVL）脑损伤的早产儿（男25例，女17例）随机分为EPO治疗组（22例）和常规治疗组（20例），治疗组于生后3—5d予以EPO治疗4周。所有患儿于纠正胎龄40周进行新生儿行为神经检测（NBNA），随诊至6个月，定期行头颅影响学检查、脑电图检查，3、6个月时分别进行发育商（DQ）测定。结果治疗组患儿NBNA评分及DQ评估均明显高于对照组，差异有显著性（P〈0．05）。结论EPO能促进神经系统损伤修复，对脑损伤的早产儿神经行为发育有促进作用，可改善预后。
Objective To study the clinical curative and protective effects of erythropoietin（EPO） on treating the premature infants with brain damage. Methods Forty-two premature infants with periventricular leukomalacia were divided into the EPO treatment group （ n = 22 ） and control group （ n = 20）. From postnatal day 3 to 5, the EPO treatment group received EPO for 4 weeks. Neonatal behavioral neurological assessments （NBNA） for all infants were performed separately in 40 weeks after correcting gestational age. All infants were followed up until 6 month after birth,MRI and electroencephalogram were performed. The developmental quotient（ DQ） was evaluated at the age of 3 and 6 months. Results The NBNA scores of EPO group in 40 weeks and DQ were significantly higher than those of control group （ P 〈 0. 05 ）. Conclusion EPO can rehabilitate the damaged neurological system of premature infants with brain damage. Early EPO therapy can promote development of the neurobehavioral and improve prognosis.
出处
《中国小儿急救医学》
CAS
2011年第1期47-49,共3页
Chinese Pediatric Emergency Medicine
关键词
促红细胞生成素
脑损伤
新生儿行为神经评估
早产儿
Erythropoietin
Brain damage
Neonatal behavioral neurological assessment
Preterm infant
