摘要
目的通过测定缺氧缺血性脑病(HIE)新生儿用药前后血清、脑脊液(CSF)促红细胞生成素(EPO)水平,探讨EPO的药代动力学变化及透过患儿血脑脊液屏障的情况。方法对35例48 h内收入院的中、重度HIE患儿随机分为用药前组10例,观察组25例。入院后观察组立即予重组人促红细胞生成素(rhEPO)500 U/kg皮下注射。其中用药后3 h组10例,8 h组8例,24 h组7例。用药前组在常规治疗前,观察组在给予EPO后的各时间点分别抽取静脉血、CSF,采用放射免疫法测定血清、CSF中EPO水平。结果观察组血清EPO水平3 h达峰值,是用药前的2.6倍(P<0.01),用药后24 h仍高于用药前水平,但无显著性差异。CSF中EPO水平也在用药后3 h达高峰(P<0.05),但在用药后8 h回落至用药前水平。观察组用药后3 h血清与CSF中EPO水平呈直线相关(r=0.69 P<0.05),而其他组间未发现相关性。结论EPO能通过HIE患儿的血脑脊液屏障,CSF中EPO水平与血液EPO水平有关。
Objective To explore the pharmacokinetics and possibility to pass through the blood brain barrier of the recombinant human erythropoietin （ EPO ） in neonate with hypoxic - ischemic encephalopathy （HIE） by measuring the erythropoietin concentration in blood and cerebrespinal fluid （CSF）. Methods Moderate and severe HIE infants were randomized to pre - treatment group （ n = 10 ） and treatment group of 3 h （n = 10）, 8 h （n =8） and 24 h （n =7）after a single subcutaneous EPO administration with a dose ofS00 U/kg, The EPO concentration in blood and CSF were measured by imunoradioassay. Results The EPO concentration in blood reached peak at 3 h after treatment, which was 2.6 times higher than that in before treatment patients（ P 〈0. 01 ）. It decreased after that and still kept high level at 24 h after EPO administration even though no significant differentce. The EPO concentration in CSF had a similar tendency with that in blood and reached peak at 3 h post EPO injection, which was significantly higher than that in patients of before treatment（P 〈0.05 ）, but it recovered at 8 h. Regression analysis showed that EPO concentration in blood and CSF was positively correlated at 3 h after EPO administration （ r = 0. 69 P 〈 0. 05 ）. But other groups had no correlations. Conclusions EPO can pass through the blood brain barrier in HIE infants. The EPO concentration in CSF is eorrelatod with EPO concentration in blood.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2007年第8期622-623,共2页
Journal of Applied Clinical Pediatrics
基金
河南省医药卫生创新人才基金项目资助(2004107048)
关键词
促红细胞生成素类
婴儿
新生
窒息
缺氧缺血
脑
erythropoietins
infant, newborn
asphyxia
hypoxic - ischemic, brain
