摘要
目的:通过检测脑梗死患者急性期凝血—纤溶活性改变,期望为脑梗死的防治、疗效观察、判断预后寻找有效的监测方法。方法:本文选择114例脑梗死患者和90例健康对照者作为研究对象,且根据神经功能缺损评分将脑梗死患者分为轻、中、重三组,采用免疫比浊法测定血浆纤维蛋白原及D-二聚体水平,进行对比分析。结果:脑梗死组血浆纤维蛋白原及D-二聚体水平均显著高于对照组(P<0.01),脑梗死患者轻、中、重三组间血浆纤维蛋白原及D-二聚体水平均有显著差异,且重型组的纤维蛋白原及D-二聚体增高最显著(P<0.01)。结论:脑梗死患者急性期体内存在凝血—纤溶系统异常。血浆纤维蛋白原及D-二聚体水平增高与脑梗死病情严重程度呈正相关,在疾病诊断、病情观察和预后判断中有一定的指导意义。
Objective To observe the changes of coagulation-fibrinolysis system in the patient with acute cerebral infarction and assess their clinic signiference.Methods The plasma fibrinogen（Fg） and D-dimer in 114 patients with acute cerebral infraction and 90 healthy controls were measured.According to the nerve function defect score,the clinical severity of 114 patients with acute cerebral infarction were graded into three groups（mild,middle and severe）.The correlation between the levels of Fg and D-dimer and clinical severity of cerebral infarction was investigated.The levels of Fg and D-dimer were measured by immunoturbidimetry.Results the levels of Fg and D-dimer were significantly higher in patients with acute cerebra infarction than those in controls（P〈0.01）.The levels of Fg and D-dimer were markedly difference among three groups.The levels of Fg and D-dimer were the highest in the severe group patients（P〈0.01）.Conclusions The levels of Fg and D-dimer in patients with cerebral infarction are higher than those in the controls and are ralated to their clinical severity.The coagulation-fibrinolysis system in patient with cerebral infarction is abnomal,which may play a pathogenetic role in onset of acute cerebral infarction.Thus adequate manipulation of abnormal coagulation-fibrinolysis system is an important therapeutic strategy in acute cerebral infarction.
出处
《心脑血管病防治》
2011年第1期19-20,23,共3页
CARDIO-CEREBROVASCULAR DISEASE PREVENTION AND TREATMENT
