摘要
目的观察甘草汤对大鼠心肌缺血再灌注损伤的影响,并探讨其机制。方法采用结扎左冠状动脉前降支15min,再灌注30min后制备大鼠心肌缺血再灌注模型,以再灌性心律失常、血清NO含量和心肌Ca2+-Mg2+-ATPase活性为观察指标。结果甘草汤组动物再灌注心律失常发生率低于模型组(P<0.01),血清NO含量显著提高(P<0.01),Ca2+-Mg2+-ATPase活性明显增强(P<0.01)。与心律平组比较,甘草汤组各项指标无显著性差异(P>0.05)。结论甘草汤对心肌缺血再灌性心律失常具有保护作用,其机制可能与提高NO含量,减轻钙超载有关。
Objective To observe The effects of Gancao decoction on myocardial ischemia-reperfusion injury in rats and its mechanism.Methods Myocardial ischemia-reperfusion injury model was induced by ligation of the left anterior descending coronary artery 15min followed by 30min reperfusion.All the indexes（reperfusion arrhythmia,serum NO and myocardial Ca2＋-Mg2＋-ATPase activity） were measured.Results Compared with model group,the incidence of reperfusion arrhythmias of Gancao decoction group was obviously decreased（P0.01）,serum NO were significantly elevated（P0.01）,Ca2＋-Mg2＋-ATPase activity was markedly increased（P0.01）.Compared with propafenone group,all the indexes of Gancao decoction showed no significant differences（P0.05）.Conclusions Gancao decoction is protective to heart against ischemia-reperfusion arrhythmia,of which the mechanism may be related to increasing NO content and reducing the Ca2＋ overload.
出处
《湖北中医学院学报》
2011年第1期9-11,共3页
Journal of Hubei College of Traditional Chinese Medicine
基金
湖北省教育厅重点课题(2001A04012)
关键词
甘草汤
缺血再灌注损伤
一氧化氮
ATP酶
Gancao decoction
Ischemia-reperfusion injury
Nitric oxide
ATP enzyme
