摘要
观察甘草次酸钠（ＳＧＡ）对培养乳鼠心肌细胞损伤的保护作用。结果：ＳＧＡ０．１０、０．２０和０．４０ｍｍｏｌ·Ｌ－１能减少缺糖缺氧６和９ｈ心肌细胞乳酸脱氢酶（ＬＤＨ）的释放；ＳＧＡ０．１０，０．２０和０．４０ｍｍｏｌ·－１对缺氧再给氧损伤６、９ｈ的心肌细胞有相似的保护作用；ＳＧＡ０．１０、０．２０和０·４０ｍｍｏｌ·Ｌ－１亦可减少氯丙嗪和黄嘌呤－黄嘌呤氧化酶损伤６，９ｈ及丝裂霉素Ｃ损伤２４ｈ心肌细胞ＬＤＨ的外漏。
The protective effect of sodium glycyrrhetinic acid(SGA) on injured myocardial cells from neonate rats was investigated.SGA 0.1, 0.2 and 0.4 mmol·L-1 reduced the release of lactate dehydrogenase(LDH) from myocardial cells injured by deprivation of oxygen and glucose at 6 h or 9 h.So did SGA 0.1, 0.2 and 0.4 mmol·L-1 in myocardial cells injured by reoxygenation after anoxia at 6 or 9 h. The chlorpromazine-demaged and xathine-xanthineodaseinjured myocardial cells could also be protected by treating with 0.1,0.2 or 0.4 mmol·L-1 at 6 or 9 h. The same results were found in myocardial cells injured by mitomycine C at 24 h.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1996年第1期74-76,共3页
Chinese Pharmacological Bulletin
关键词
甘草次酸
心肌细胞损伤
乳酸脱氢酶
glycyrrhetinic acid
myocardium
cells
injury
lactate dehydrogenase
