摘要
腺嘌呤与(R)-环氧丙烷缩合得(R)-9-(2-羟基丙基)腺嘌呤,经醚化、水解得到泰诺福韦,再经氯甲基碳酸异丙酯酯化、成盐制得抗病毒药富马酸泰诺福韦酯,总收率约21%。
Tenofovir disoproxil fumarate was synthesized from adenine via ring-opening condensation with （R） -propylene oxide,etherification and hydrolysis to give tenofovir,which was subjected to reaction with chloromethyl isopropyl carbonate,followed by salt formation with an overall yield of about 21%.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2011年第2期81-83,共3页
Chinese Journal of Pharmaceuticals
关键词
富马酸泰诺福韦酯
抗病毒药
合成
tenofovir disoproxil fumarate
antiviral drug
synthesis
