摘要
开环核苷类抗病毒药物具有低毒、低耐受性和广谱抗DNA病毒活性,其前药更是提高了药物的口服生物利用度。综述了几种常见开环核苷类药物及其前药近年的研究进展,在此基础上展望了抗病毒药物的研究方向。
Antivirus nucleoside antiviral drugs have low toxicity,low tolerance and broad-spectrum anti-DNA virus activity,and furthermore the prodrugs have improved the oral bioavailability.The research process of several common kinds of acyclic nucleoside drugs and the prodrugs in recent years was surveyed,and on this basis,the research direction of antiviral drugs was forcasted.
出处
《北京联合大学学报》
CAS
2010年第2期29-34,共6页
Journal of Beijing Union University
基金
山东省自然科学基金(Y2008B27)
山东省优秀中青年科学家科研奖励基金(2007BS04021)
