摘要
目的探讨不同病情下采用蒙特卡罗模拟结果应用亚胺培南的治疗效果。方法选择367例感染患者,治疗前对患者进行APACHEⅡ评分,<20分患者延长给药时间组73例,常规给药组70例,≥20分患者延长给药时间组114例,常规给药组110例,延长给药时间组参考蒙特卡罗模拟结果,给予亚胺培南/西司他丁[0.5g,1次.(6h)-1],并且将总输注时间延长至3 h,常规给药组给予亚胺培南/西司他丁[0.5 g,1次.(6h)-1],每次输注时间30 min。两组都给予相关的高级生命功能支持及营养支持,其余辅助治疗相同。结果 APACHEⅡ评分<20分患者采用亚胺培南延长给药时间与常规给药方法疗效、预后、住院时间无统计学差异;而APACHEⅡ评分≥20分患者采用亚胺培南延长给药时间的给药方法在疗效、预后、住院时间皆优于常规给药方法。结论在危重感染的情况下延长亚胺培南滴注时间的给药方法可使患者获得更大的益处,这也为合理应用亚胺培南提供依据。
OBJECTIVE Discusses under the different condition to use Monte Carlo the Simulation result to apply imipenem the treatment result.METHODS Chooses 367 infection patients,before the treatment carries on APACHE to the patientⅡGrading,20 patient lengthens for the medicine time group 73 examples,the convention for the medicine group 70 examples,≥20 patient lengthens for the medicine time group 114 examples,the convention gives the medicine group 110 examples,The extension refers to Monte Carlo for the medicine time group the Simulation result,and gives imipenem 0.5 g,q6h to lengthen the total infusion time to 3 h,the convention gives for the medicine group imipenem 0.5 g,q6h,each time infusion time 30 min.Two groups both give the correlation the high-level life function support and the nutrition support,other assistances treat same.RESULTS APACHEⅡGrades 20 to divide the patient to use imipenem to lengthen for the medicine time and the convention gives the formula law curative effect,the prognosis,in hospital time non-statistics difference;But APACHEⅡA grading ≥20 minute patient uses imipenem to lengthen for the medicine time for the formula law in the curative effect,the prognosis,in hospital time all surpasses the convention to the formula law.CONCLUSION Lengthens the imipenem drop note time in the seriously injured infection situation to be possible to cause the patient for the formula law to obtain a bigger profit,this also for reasonably provides the basis using imipenem.
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2010年第12期1134-1137,共4页
Chinese Journal of Modern Applied Pharmacy
基金
广西科技厅青年基金资助课题(桂科青0991093)
关键词
亚胺培南
蒙特卡罗模拟
延长给药时间
imipenem
Monte Carlo Simulation
extension gives the medicine time
